Transcript
PCAvPGtNPKo • Interview: Consciousness, Personality, and Creativity with Heather Berlin | Particles of Thought
/home/itcorpmy/itcorp.my.id/harry/yt_channel/out/novapbs/.shards/text-0001.zst#text/1086_PCAvPGtNPKo.txt
Kind: captions Language: en When you solve a puzzle, >> that's a good feeling. Yeah. >> And and there's evolutionary reasons for why our brains evolved to find pleasure in solving problems. And I think finding meaning in in ambiguous things and finding purpose, it gives us a sense of this pleasure, this contentment. [Music] >> Heather. Yes. >> Welcome. Thank you so much for coming to Particles of Thought. >> Thank you for having me. >> Yes. I am so excited to talk to you because you are a neuroscientist and psychologist. Is that correct? >> That is. >> My brain got issues. Right. But before we get into all my issues, let's start at the very beginning because when we're talking about the brain and what you do, we are talking about consciousness. >> But I'm not sure I know what that is. How do you define consciousness? >> Oh, just easy question right off the bat. I uh I I have a very simple answer, but it took us a long time to get to this. Okay. >> So, one time they brought together all the sort of these world experts, neuroscientists, philosophers, psychologists. We we went to this retreat um I think it was in Aspen for a week and all we had to do was >> discuss we had whiteboards we had you know for the whole is just come up with a definition of consciousness. Oh, interesting. >> You know, so I'd be like writing it down and this agreed. Do you agree? This and finally after the end of this whole week, >> right? >> What we all agreed on is very simple. It is first person subjective experience. >> So does that mean you have awareness? That's what first person means. >> First person is only you have access to it. >> Okay. >> Okay. So I don't know that you're conscious. I'm only have access to my own awareness, my own and it first of all, you don't need language for it. You don't need intelligence. You don't need a sense of self. >> It is pure subjective >> sensation perception. So just simply experiencing pain. >> Okay. So does one need a brain? So can a instrument like that has a neuronet a creature that has a neuronet versus one with a brain do they both have consciousness? It depends on what our fundamental theory of conscious of the of what's the basis of consciousness the material basis of consciousness and that's something that's fascinated me for basically my entire career is >> right now we know I know I have it >> material basis >> material basis of consciousness so it's this subjective experience that we have and we assume other animals have it because we have a similar evolutionary history they act as if they're conscious if you step on a cat's foot it yelps as if it's feeling pain >> right >> we if you look at the hardware it looks pretty similar like a little you know square you know cubic millimeter of cortex of a monkey will look very similar to ours. Oh. >> Um, so we assume other animals have it and you go how far down the line then it starts to get questionable but you know bees, fish, ants. >> So we know that it's something that has to do with the nervous system. But could it be instantiated in other matter, >> right? Or even non-living matter >> or non non-living matter, silicon, whatever. We will only know for sure if we have an agreed upon fundamental theory of conscious theory of consciousness. And there's several out there. They're leading contenders. We're we're actually pitting them against each other experimentally in this big study that's going on across the world. If say the integrated information theory of consciousness wins out IIIT, which says any system that basically has like a high degree of integrated information, >> differentiated integrated information will have this property of consciousness. >> Then it's substrate independent. Meaning you could have any system. The brain just happens to be one of these systems. Right. >> But theoretically you could extend it could be a non-organic matter. >> So what got to me there what stood out to me is you use the word integrated because >> sensor it's not just having sensory data >> that forms consciousness right because you know there are simple single cell life forms that know oh bad stuff here I need to move that way. approach, avoid. An amoeba can approach, avoid. >> Yeah. But they're not conscious, >> right? Or it depends on how you define what we mean by consciousness. >> But they're there's no evidence of integrated knowledge on their part. >> Right. Yeah. Right. >> So memory doesn't equal consciousness then. >> No. Cuz we could have what's called implicit memory, which is memories that we don't we're not consciously aware like motor memory, right? you know, riding a bicycle, you're not thinking about it. I mean, if you if you put your attention on it, then you can make yourself conscious of it or tying your shoe. When you're first learning it, it's explicit. You're very conscious. You're thinking about it >> once it becomes habitual. You no longer need to think about it. Becomes unconscious memory. So, so >> memory doesn't and then it moves to different parts of the brain depending on if it's explicit or implicit, right? >> But so memory in itself doesn't have to be conscious. It's just pure subjective experience. Philosophers call qualia. But like the redness of red, experiencing just seeing the color red, not it's me experiencing this red or this red reminds me of the red on the Chinese flag or whatever, >> right? >> It's just pure sensation. So other animals have this. We just have then higher levels of complexity on what we do with that pure sensory information and that perception. >> Right. Right. Right. Okay. >> Yeah. So >> So simple. I don't know if we understand what consciousness is anymore, but it it >> Well, I would say it's like that thing that for you, for us, yes. What you experience when you first wake up in the morning and >> experience anything, your first sensations, it's everything we experience until we go into a deep dreamless sleep. >> Um, but most of what's happening in our brain is happening outside of awareness. We're only conscious of very little bit because it takes a lot of processing to bring things into consciousness. Most things are happening outside of awareness. >> Right. Right. >> But it's subjective. I only And when we test people, I have to ask you, did you see this or not? Were you aware of this or not? And that's where it becomes difficult with animals. We have to come up with tricks on how to >> test it experimentally or a person in a coma if they're conscious or not. >> Well, that's what I was going to get. Is there a way to um There are different states of unconsciousness. You could be asleep. You could be a nesticized. You could be in a coma. >> So, in comparison to the awake brain? Yes. Yes. Or what even about even altered brain states if you're on some sort of hallucinogenic, right? Do you see you know >> gradations? Okay. So, so if you think of it like there's um you know you think of it like this scale there's there's awakeness and awareness. Okay. >> So >> the brain needs to be fully awake to be aware of anything. So there is different levels of >> wait a minute wait a minute I as an example. Okay. >> When I was very very young, I was a bed wetter. >> Okay. >> Then I realized, oh, if I'm having a dream that I'm about to go, I need to wake up. And I developed the ability to do that. So, it's like I had consciousness while I was unconscious. >> But here's the thing. When you're dreaming, >> yeah, >> we tend to be in this sort of REM sleep stage, which when you look at the brain activation, looks like an awake brain. >> So, when you're conscious in your dreams, you're you're asleep, but you're aware. So, there's there's Dreams are kind of an anomaly. So if you're looking at this scale of how awake the brain, so you have like, you know, fully awake, then you have different stages, you know, sleep, coma, this and that, then you have how aware you are, >> right? >> But dreams are really interesting because they're outside of this like line here because it's you're asleep, but you're aware, >> right? And that's because the brain's in this interesting state where your prefrontal cortex is kind of not is is you know decreasing activation but your your when you look at the activation of the brain it looks as almost like the awake brain in terms of EEG. >> Yeah. Yeah. >> So it's a unique state but you are conscious when you're dreaming that's consciousness even though you're asleep. So yeah it's not a onetoone correlation. >> Right. Right. Um but but we assume that you have to kind of be fully awake outside of certain anomal like dreaming >> to be aware of anything and then we usually when we're testing consciousness we say in a fully awake person not in a coma not under anesthesia >> do you see it or not are you conscious of it or not right >> but then you have different levels of consciousness in terms of sleep of you know awakeness let's call it >> consciousness is related to what you're p putting your attention on >> not necessarily so there's studies that show there's actually there can be a dissociation between attention and consciousness. So usually they coincide with one another but there are ways in which we can tease them apart where you can be have attention separate from consciousness >> which gets us into the weeds. God >> so sometimes though we equate consciousness with awareness. We'll say awareness but attention and consciousness um are two different things. Right. Well, I guess what I was getting at is a lot could be going on around you, but if you don't pay attention, you're going to be unaware, right? >> Usually, yeah, >> your brain is like filtering or something, >> right? That like sort of, you know, you're at a cocktail party and you're talk I'm talking to you, >> but suddenly I my brain hears my name over there in this conversation. Suddenly, I'm looking at you, whatever, but I'm my attention, my auditory attention is here, and now I'm tuning into what they're saying over there. And you can refocus your attention, right? So certain things grab your brain's attention. Change does novelty does your brain some, you know, word that might be significant to you >> and you shift your awareness. >> Yeah. And your attention >> and in preparing for uh chatting with you today, I looked up, you know, some of the your your previous interviews and I saw this notion of a perception box. >> Yes. >> Right. >> Yeah. >> And it really kind of, you know, shook me. And let me tell you why. Because as a scientist myself studying reality, I run up on these points where I'm I make discoveries like, oh, time ain't time, >> right? And I end up at places where I'm like, oh, do I even exist? And now it's almost like you're telling me that my perception of the world in some ways it seems it's obvious but this break apart the idea of a perception box and how that determines one's experience of and defines one's experience of reality and ultimately does that mean reality is reality if it's a perception box dependent thing. So we we perceive reality or the world like maybe there are fundamental objective truths out there. I think the best way to get to them is like through the scientific method because we're all inherently biased because we are perceiving reality. It's being actually constructed for us by this filter of the brain. >> Okay. >> Each one of our brains is different. So it's like a thumbrint, right? Each brain has its own unique neural, you know, setup, architecture, and >> and history. >> Yeah. your your exactly what you've been exposed to, the way your brain has developed over your lifetime, your genetic predispositions. So, we're all there's a lot of similarities, but there's also definitely we're each unique in terms of our brain. >> So, given that our organ that helps us perceive the world is different. We all are seeing the world in slightly different ways depending on our history and our genetics. And so the brain is constructing it's there's not it's dark in there, right? It's it's dark. >> That is such a brilliant Well, but I once heard someone say that your teeth are the only part of the skeleton that you see on the outside. Your eyeballs are the only part of the brain that you see on the outside. >> Right. Right. Right. Cuz there's Right. But but they're really just nerve endings, >> you know? That's all it is. And it's a series of ones and zeros, you know. It's just information coming into this machine that doesn't actually see anything. >> So the signals it takes as input >> are from the ears, from the eyes, from the >> five senses. Yeah. >> And and they're like chemical and uh Yeah. Exactly. electrical and chemical signals. Okay. Then our brain constructs this into a >> subjective perception. But our perception does not correlate one to one with reality with objective reality. So >> let's let's define the word perception here. >> Okay. What how we how oh that's difficult. That's harder to define. >> Just receive sensory data. >> You're receiving sensory data and then you're forming a a sort of percept image or a like a sound. The way we construct how we're either seeing or hearing the world, let's say, or feeling it. And it's constructed by the brain like like it's it's sort of making a movie of what it thinks is happening out there based on this data >> and our our biases. So if you think of it like this, you have this sort of stream of information coming in from our our all of our sensory organs. Yeah. >> So that's coming in one way. Then we have this top- down processing of what we expect things to be based on our history and what we've seen before and and because we can't look take each individual case each as something new. It would be too much processing, right? So we have heristics that we use and expectations and where that data coming in meets with our expectations. That's where we form >> our we construct our reality, our sense of what's happening out there. >> And it's all slightly different for each person. So what you that's why two different people can have completely different belief systems and views of the world and see things in completely different ways based on what they expect to see, what they want to see, what their biases are, and what's how they're processing the information coming in >> and how they voted in the last election. >> That's exactly right. Which determines everything. >> That determines everything in America. Yeah. >> But so that's we're seeing the world through our own perception box, right? And everyone really believes theirs is really real. But certain things, psychedelic drugs, meditation, flow states can expand our perception box. So we can have maybe we're all living in these tiny boxes. If we can widen it, we can understand other perspectives or see things in a slightly different way. >> Yeah. Oh, I I you know, I've experienced this personally because I lived in um the deep south >> before in the 20th century, right, in a very rural area and um I didn't have access to much of humanity, right? It was it was, you know, traditional populations in that location. And I leave there and go to graduate school in the San Francisco Bay area, >> right? >> Dramatic shift. >> The grocery store is different, right? you know, every everything is uh new. And uh I learned that a lot of the narratives that I had in my mind of the way the world worked, how the world was going to interact with me was were completely gone. I mean, were completely wrong. But I was perceiving them from that. You know, the guy I was at age 24 stepping into the Bay Area, the guy I am now who's now been to countries all over the world, you know, every state but three, >> very different. >> Yeah. And you wouldn't know it though when this a similar thing happened with me. you know, I grew up in New York and I mean, which is a very diverse, you know, place. But then >> when I moved to go to the UK, I went I studied abroad and then went to graduate school and then I traveled around Europe and then I start and suddenly I had this whole other perspective and I viewed America differently and whatever because it used to be like, okay, and also within America, I'm the North, you're the South, we're very different, but then when we're over there, oh, we're all the same, they're, you know, >> and it brought into your perspective. It's a really good and I think everybody should try to get out of their own, you know, >> right? Yeah. >> comfort zone. >> Well, at least you can and then I think you get closer to the truth of things. >> Yes. >> You know, it it's standard observational science that the error in your measurement is dependent upon the number of measurements you make. The more you make, the more accurate you become. Right? So the more you observe humanity in its different environments, in its different manifestations, the better you understand people. And I came to the conclusion we're all the same. >> Yeah. Well, I mean, look, you know what? When you look inside, like look at a brain. >> Yeah. >> Right. >> You can't tell what nationality, what race, what whatever. It looks pretty much the same. You can tell a lot of the time. You can tell male, female. There's certain characteristics, but outside of that, you know, everyone's brain is looking the same on the inside. >> Yeah. What you saying earlier is that, you know, if you have a slice of brain, you can't tell whether it's human or even another species. >> Yeah. Yeah. >> So, it's like we're all much more similar than we think. Yeah. >> So, how does our personality maintain itself? Is it is it there is there some underlying activity that you know when we're awake it it establishes our personality and you know >> how how does this human >> expression happen >> you know I did I actually did a lot of research um earlier on on personality I was really interested in this and like what's the neural basis of personality what's interesting is is personality is very consistent across life like you see there's there's some minor variations as you get older you get there's some changes But in general, you take a a baby who's and you look at their temperament, >> you can pretty much predict their kind of personality throughout life like and I can tell you this even from being a mother. >> I have two children, you know, in uterero feeling them and the way they acted and whatever, they were very different. You know, one was much more active, one was more active at night, the other and like this and the way the other temperaments as babies and then, you know, it really carries through. So, so I really think what we call personality is is really and the way it's kind of defined is a consistent way of behaving across different environments and settings. So that we're looking for at personality is what is consistent about you across time, right? And that I think is a huge genetic component. >> But then our brains are living evolving creatures, let's say. They're never it's always changing. This is why I we can get into this conversation. you know why AI in its current form I don't think is going to be conscious or we we'd have to build a neuromorphic computer that changes with inputs constantly because our brain is always changing till the day you die >> it is changing now it's like a piece of clay it's really malleable early on and it starts to harden and get stiffer and harder to mold but it's always changing >> okay >> so we have these basic let's say our our fundamental roots of who we are >> our core personality you know you're a grumpy person you're what you tend to be happy golucky as a baby you're going to tend to eat throughout life. And there's even studies that show, you know, if you win the lottery, >> you will maybe if let's say you're you're a grumpy sad person, you'll get a blip of happiness and you go right back to where you were before. And by the way, also if some tragedy happens, you lose your legs. You can no longer walk. >> You're you're happy golucky person. You get a blip of down and then you become that person again. So even regardless of, you know, very impactful things that can happen in your life, personally stays consistent. But that being said, >> yeah, >> a lot of change and learning goes on within those. So there I think there's certain boundaries that we're in that are that genetics set, but within that we can either be at one end or the other depending on our experiences. But like if you're an anxious person, you're never going to be the most relaxed person in the room, but if I'm treating you as a patient, I this is your boundaries. I can get you from here to here, but I'm never going to get you over to here because there's certain limitations. >> I see. Wow. Wow. So that says a lot about parenting. >> Oh yeah. >> You're not the molder of your children. A lot of it is already uh established before >> while they're even still inside. And the research shows if you look at, you know, Steven Pinker and he's written a lot about this and the blank slate that >> parents it's very hard even as a parent myself it's it's so counterintuitive but really >> there's not unless it's extremes like extreme abuse or something then that can have an impact. But within the sort of normal bounds >> what you do as a parent doesn't have that much impact. >> Friends do. So what you can do as a parent is make sure you get them in a place that might be that they're going to be with the right kind of peers that you want to have an influence on them >> so their peers influence them their their friends parents can influence them socially and they'll be more likely to listen to them. >> Yeah. >> So you can do as a parent is put them in a right environment. >> Right. >> But all this stuff that we think is having such a huge impact isn't. And actually as you get older the um influence of genetics becomes stronger >> really. has more of an impact your genetics as you get older. >> Um, so it's like, you know, just be a a kind, loving, do what you can, but don't so either one, you don't, it's great because you don't get to blame yourself for when, you know, it's not your fault, but also you don't get to take all the credit, you know, when they do extraordinary things. >> Yeah. Yeah. They are their own little human there. >> Yes. You help them. I I see my children as I'm just there to help nurture them, help them become who they're supposed to be. This podcast is from the producers of Nova. Nova is supported by Carile Companies, a manufacturer of innovative building envelope systems. With buildings responsible for over a third of total energy use, Carile's energy efficient solutions are built to reduce strain on the energy grid. For example, Carile's Ultra Touch Denim Insulation made from sustainable recycled cotton fibers delivers energy efficiency while being safe to handle and easy to install. Made with 80% recycled denim, Ultraouch diverts nearly 20 million pounds of textile waste from landfills each year. Operating across North America, Carile is working towards a more sustainable future. Learn more at carile.com. Let's play a little game. >> Okay. >> And the game we're going to play is What's My Brain Doing? >> Okay. >> All right. >> Yes. >> I'm having deja vu. >> Oh, that's a hard one. >> Oh, >> damn it. Deja Vu. Okay. >> Is my brain quantum entangled with my future self? >> No. >> Okay. >> That I wouldn't go that far. I mean, you never know. I don't know. >> You never know, right? astrophys, you know, at a distance, whatever, >> entanglement. But what I think is going on is that um >> we have a sense, we have a part of our brain that gives a sense of familiarity, right? >> Something feels familiar to us. >> Oh, >> and I think it's a little sometimes our brain does these little like missteps or misfires to things. So, you might walk into a room and you suddenly get this sense of this feels familiar to me. It feels like I've been here before, you know, and so your brain then reconstructs the reality. It's trying to make sense of it. >> Yeah. >> And then you sort of get this feeling of deja vu. Oh, I've been here before. I've seen this before. >> You know, and even we can mess around with people's time perception and I did a lot of research on during my PhD about our what's the neural basis of time perception? How do we perceive time? And there's a neural different we can link it to certain you know and people have certain brain damage. they perceive time differently or certain psychiatric illnesses. So we can link it to underlying neural coralates and we can also play around with when a person perceives that something happened in time. So I can have something happen to you and then we do something TMS, transcranial magnetic stimulation, put a little magnet here, zap you a little and suddenly you're like, "Oh no, it happened over here." You >> can stimulate my brain to change the place in time where >> where you feel things happen and also your sense of agency. How much control did I have over that movement? And so our brains are tricky because we're also constructing our sense of time. So I think there's like sort of these little trip wires in the brain where things you know there are little flaws in the matrix like that's what illusions are right when we discovered the little holes in the brain is constructing things but it's not perfect and when things don't make sense like we I say you know brain is a meaning maker machine. It wants to make meaning out of things. So you walk into a room suddenly things feel familiar. You're like then it starts to construct a new reality. Oh, I must have been here before. >> Is there a novelty center as well? Like you said, there's a familiarity center. There's >> I mean, I wouldn't I hesitate to call things centers. I'd say circuit circuit. Yeah. But yeah, of of course um novelty. I mean, our dopamine, >> yes, >> is released with novelty. Our brain loves novelty because it's important for us to attend to things that are novel because that could be something dangerous. It could be, you know, it says like, "Hey, pay attention to this thing, >> right?" So um it's more related to attending to things but novelty sometimes when it's associated with pleasure as well and you get nuclear circumbent activation we tend to like novelty >> because it evolutionarily it makes sense to attend to things that are novel for better chances to survive. Right. >> Right. Right. Right. Okay. So back to what's my brain doing? >> Okay. >> Suppose I'm watching something or I listen to something particularly moving and I get goosebumps. >> Yeah. >> What's happening? So that that is an interesting thing and I I think um it has to do with this feeling of sometimes with awe, this sense of awe. Yeah. >> Right. Where you hear a piece of music, you see a vista, you have some emotional something emotional that triggers you. It's very >> much related to like a brain stem. Um it's lower in the brain. It's a very physiologic reaction that we something triggers us maybe emotionally and then it triggers this this >> nervous system response. >> Yeah. >> It's an automatic response just like crying is you know this auto automatic nervous autonomic nervous system response where >> oh really >> it's almost like you don't have you don't have control over it >> but it can be triggered by different emotional experiences. >> Interesting. You know sometimes we have questions of what do other animals think or feel. >> So is it the case that those fundamental basal feelings like awe >> what leads us to cry manifest similarly in other mammals or you know does it have to be other primates or >> I do think that other animals have basic sensations like this but we interpret them differently. So and that for example you know you can have a certain physiologic sensation in you like you feel butterflies in your stomach or something and then once we get that sensation then our higher cortices prefrontal cortex starts to interpret that as either oh I'm really anxious about something or I'm really nervous or I'm really excited about this thing and we could reinterpret the same physiologic sensation in different ways >> and so other animals might just have sensations and not interpret them so they they don't sort of elevate them to these other to to you know you might start feeling some sensation of crying then you start thinking of oh my god I'm thinking of my grandmother or whatever and then it becomes more and more and more and it kind of >> you know elevates it so I think other animals have different feelings but they don't have these more complex feelings that we have like like envy and you know jealousy or lust and because they don't also can't think that far into the future they don't have as involved prefrontal cortex which thinks about the future right so Anxiety is really a very human emotion because it's about fear of something bad happening in the future. Animals have fear other animals, >> but not so much anxiety here now. >> Yes. It's the things that are happening right now, but not like, oh my god, in two days I'm going to have this exam or I'm going to have so they don't have these more complex emotions that we have. But there's these beautiful images like, you know, with with um Jane Goodall, you know, and there's these apes looking out at the vista and it looks as if they're, you know, >> oh, really? They're experiencing the beauty and >> the beauty or animals like like Yak Pangep um was someone you know a colleague I knew for a long time. He unfortunately passed away but he was talked about these >> rats that would like tickle you can tickle the rats and they would laugh. He recorded their like laughter and they would play and they would you know so they're they're experiencing things you know like joy. Um but it's just very much in the moment. >> Right. Right. Wow. That is something. What about when, for example, I leave my keys in the refrigerator? What has my brain done? >> I think you need to come to my office. >> Oh, you ain't heard nothing yet. We Oh, boy. I >> Do I need treatment? >> Um, >> so misplacing objects. >> Misplacing objects. I walk into a room, I forget what my thought was. You know, these forgetful me or I'm looking for my keys and they're in my hand the whole time, >> right? Yes. >> Yeah. So various reasons, not one answer for everything, but the the sort of elements that seem to be involved are are attention. So you might have had an intent to go into a room, >> right? And then your first of all, your mind is wandering. You know, you're think then you start thinking about what's my grocery list? Oh, what's the thing I got to do later? Whatever. So now you that memory of why you went in the room slipped away. you knew there was a purpose of going in there but you had moved on to other things. >> Yeah. My brain started thinking about something else that's why. Yeah. >> And then suddenly you're like why am I why am I here or you know so a lot of it to do with with attention and memory and there's different parts of the brain that do like like the dorsal prefrontal cortex has to do with working memory. So that's like >> um you know when you're trying to remember like four four digits seven digits a number something you got to keep it on saying it over and over again. But then when you have something in more long-term memory, it get moves over to the hippocampus. >> Oh, >> but usually these things like your keys, where you're putting them, whatever, that's the kind of working short-term memory. And if you don't stay attending to like what you're doing or focus on where your keys are, it's going to slip away cuz your mind starts attending internally to other things. >> Especially people with ADHD, it becomes even harder. Um and then yeah, of course with age there's normal aging brain that where you know memory starts to get not as sharp and >> but so if you really want to remember where your keys are or whatever you have to stay focused on that. So if you're like I know I'm going in this room and keep remembering why you're going in the room I'm going to get my keys get my key the second you go off that you're it's done. You're done. I know that I tell I tell people that when I work with them. I was like, "Listen, if we say >> if we come up with a task for me, make sure you see me, put it in my calendar right >> before." >> And I always say this like, "Do it now. Write it down." Absolutely. You think you're going to remember, you're not going to remember. You're not. Yeah. I know I'm not. Yeah. So, I always tell my students, never take work out of the room. If you if you can avoid it, don't take work out of the room. Get it done. >> Do it now. And And if not, just write it. Write it down. Write it down. Don't trust your brain that much. >> Now what? Let's talk about drugs. So >> Oh yeah. >> What happens you know in in for example when someone takes hallucinogenics >> uh you know it's kind of like dreaming because your brain has created stuff that's not happening in actual reality, right? >> Uh but you're awake. >> Yes. >> Yeah. >> It's so fascinating. So it it depends on the on the drug. Each drug >> that's why I said hallucinogenics to separate it from say marijuana, >> right? Yeah. >> So, let's talk about psilocybin, which is the ingredient in shrooms. Yeah. Psychedelic ingredient mushrooms. That's a cool one. Um, >> we've done neuroiming studies to look at what's happening in the brain when people are in these states >> and it's fascinating because what it seems to be is that I wouldn't say you're at a some people used to say it's a higher level of consciousness. No, there's no higher or lower. It's either you're conscious or you're not. >> But it's a different state of consciousness. So, we have different states of consciousness. We're experiencing the world in different ways. Now, normally in a in a non-drugged, healthy, awake brain, >> you're getting all this information. It's actually chaos. And then our brain has all these constraints to make it have a clear accurate picture, right? But you take somebody with like schizophrenia or or another, you know, mental health disorders with psychosis, they're starts they're not constructing the the reality in a constrained way. It becomes an unconstrained brain. If your brain is in that state all the time, that's not a good state to be in because you can't navigate the world. You need to be able to filter out the sort of non-essential information and construct your this reality we talk about >> because you know there is that phenomenon and in psychedelics where you're like oh that cloud looks like a dragon and then it becomes a dragon >> right because the constraints are no longer there. So what we see in the brain is that it becomes like an unconstrained brain temporarily. Now I guess like a schizophrenic is in that state all the time. That's not healthy, right? But if you temporarily the prefrontal cortex is kind of like the executive of the brain and it's kind of constraining things and making things make sense, like making meaning out of it. >> You take that filter off, you know, you it kind of your brain starts firing in a different way when you're on these psychedelics and it becomes unconstrained, which is great because anything goes creativity, you're thinking new thoughts, you're getting to access unconscious things. Like >> it's it's it's a lovely state to be in temporarily, but then you do want to go back to that like more constrained brain state. But when you're in that state, people, you know, they lose their sense of self, right? They be feel one with everything. The boundary between self and other gets sort of dissolved. >> Oh, interesting. >> People associate that with very positive experience, right? You feel like there's things greater than you. So fear of death starts to go away, you know, especially the more intense like the fiveme whatever really like the toad the drug. Yeah. Yeah, people go shoot off into space, you know, they're like, I died and came back, but they lose their fear of death >> because it becomes not about you and your ego and this construct cuz who we are is a construct of our brain, right? >> You know, we're making up our who I'm this person, whatever. So, that kind of dissolves and you get this openness. Um, and so we're starting to understand what's happening at the neural basis and it's being used now to help treat people with psychiatric illnesses like um, obsessivecompulsive disorder and depression and um, PTSD like with MDMA >> to help people get into these other brain states to help resolve some of the issues that they're can't when they get locked into these negative brain states or negative um, thought patterns >> that which reminds me there is a phrase I've used for a long time to talk about how I deal with my own brain and I call it mental engineering. And what that is is for me what I say to myself to get my self to do what I need myself to do given the way my brain is operating on its own, right? I got to sort of retrain it. So the classic example I give is flying, right? You know, I started flying relatively late in life, you know, >> in my early 30s. >> Flying a plane or being a plane being being a pastor in a plane. Yeah. And by the time I did that, you know, I had taken fluid dynamics as a physicist. I knew Bernie's equation. I understand how lift works. >> But when I get up tens of thousands of feet in the air and look down, I'm like, "This ain't right." >> Right. >> I don't feel comfortable. Right. And so, one of the things I did at that time, there was a reality show about phobias. And I remember one of the uh therapists telling the person just because you imagine something doesn't mean it's going to happen. And so I started to say that to myself, right? Like oh just because you imagine, right? And so I I I did that. Another thing is, you know, for example, when I um was early in my career, I was starting from behind. I wasn't, you know, well educated and I had to work really hard, right? And so I would tell myself these stories like, "Oh, while they're sleeping, I'm working. And while they're partying, I'm working, you know, and and and uh >> you know, and and these stories I tell myself to engineer my my mind. >> Yeah. >> Into ignoring fear, ignoring pain, >> things that would normally make me stop or prevent me from doing what I want to do. I tell myself stories. >> So, how plastic is the brain? Um, there's a few things there and we can talk about, you know, free will and how much control do we really have, but >> there is that, >> but but I love this kind of way you've put it. It's kind of an analogy. What did you call it? Mental engineering. >> Yeah. >> It it's really that's CBT. It's cognitive behavioral therapy. >> Oh. >> Because that's phrase. >> What we're trying to do in therapy is that your pain, let's just say, or your fear >> is a construct of your mind. It's of your own making. You know, people put themselves into their own cage, right? >> And if you can somehow re-engineer or change some of those thought patterns, >> you can change how you feel. You can change how you behave cuz there's, you know, the thoughts, the feelings, and the behavior, right? >> And they're all, you know, interconnected. So, you can make change in any one of those. You can change your behavior. I say to you, go on planes no matter what. And over time, your brain will realize nothing bad happens. And then you'll the fear will go away. >> Hopefully, you hopefully you can change your thoughts. But if I tell you if you have a fear of flying and everything >> I tell you about it's safe, it's all the statistics, whatever, that's not going to change your fear. You actually actually have to do it. You have to >> do it to train your brain. It's like if I tell you everything about how to do abs. >> Information isn't going to change behavior. >> No, you have to actually do it and then your brain sees, oh, nothing bad happened. I'm going to change my practice. You got to practice. And then you also can work on the the thought patterns. But perception can change our reality. So if you can shift your perception like there's you know um Carol Dws a lot about this growth mindset you know versus right and if you tell yourself I can't do it I'm never going to do then you're not going to do it >> right. Exactly. >> If you say you can do anything I remember my dad gave me advice when I was younger. It always stuck with me. It was the simplest thing but he was just like never stop yourself. >> You keep going until somebody else stops you. And even then you keep going, right? Because if you stop yourself and say, "I can't do it." Then you'll definitely not get anywhere. >> That's right. >> You go until somebody stops you and even then you keep going. Never, you know, be self-limiting. >> Right. Right. >> And because we can be our own worst enemies. >> So this idea that we can reconstruct. So in terms of how plastic we >> Let me let me vibe with you on that a couple times. There's two things. one >> when I was a graduate student and I had be got over the hurdles and I saw that there were others younger than me struggling right my advice to them was because what I saw happening is that you know you feel so dejected you feel so like less than you quit so my advice to students was don't quit let them kick you out >> right >> because they never do for the most part right and then the the the other thing that comes to mind is someone said this to me and they misqued it, but but the way I like the way they said it to me, >> I like it better than the original quote. And the thing is is um the statement goes, if you think you can do something, you're probably right. If you think you can't do something, you're definitely right. >> Right. Yes. Exactly. Exactly. You're definitely not going to get anywhere if you tell yourself you can't do it. If you tell yourself you can, there might be a chance you can do it, >> right? >> Why not? Everybody never like I don't know you know Obama like oh I'm going to be president like people what that's ridiculous >> I didn't see that one coming. >> No but you keep telling yourself I can do this I can do it and then you know what why can't you >> why can't you right >> you know you start seeing people at the top. You're like that's the person at the top. I thought there was a you know >> well I it doesn't look that way till you when you're in your 20s and your 30s. Once you get older you're like they're idiots. >> Nobody knows anything. >> Exactly. I I actually there was a point when I was like, wait, I'm the expert, >> right? >> I know the feeling. Yeah. >> Yeah. But it's like, you know, >> I like to say, you know, back in the day, we had, you know, I'm a physicist, right? We had Einstein, Drack, Paulie. Today, it's us, me and Debbie and David, right? >> Humanity is doomed, >> right? You're like, wait, we're in charge now. What happened? But the but to your question of like how plastic are we? How changeable are we? I do feel >> and are there methods? That's the other thing. >> Yes. I think everybody is capable of change as I said before with the certain constraints of our biology right >> what about introducing the psychedelics into these >> cognitive behavioral therapies >> that's a huge game changer you know someone I've been in the field of you know neuroscience and and and psychiatry and research for for you know decades and there hasn't been a fundamental shift in say treatment of psychiatric illnesses in terms of psychopharmarmacology for 50 years I mean it's all okay you have ss selective seroton reuptake inhibitors that are affecting the serotonin receptors >> and they're all like variations on a theme. we're gonna oh we're going to slightly do this other receptor now we're going to do that but it's just playing around with different combinations of drugs then you have this psychedelic psychotherapy which is a huge shift I mean I've seen people who've you know tried everything they depressed they do you know all sorts of we do deep brain stimulation you know you have to go in and plant electrodes that's neurosurgery right that's there's some risks involved there instead you can have these people have fundamental shifts in in in their symptomology with you know ketamine right now is FDA approved. So, a lot of patients are doing ketamine. >> What is the out what is it? You know, I I've heard ketamine talked about a lot recently in therapy. Can you describe that for us? >> It's amazing. I mean, look, it's not like a panacea. It's not like everyone who does it is going to get 100% better, right? >> But um for a certain population of people who have tried everything, it really can help with say depression. They give it now in psychiatric in the ER for people who are actively suicidal. It can actually just like you give it and it takes away the suicidality like in the moment for people. So it's very impactful and again it's not 100% have some serotonin and dopamine. >> So there's this glutamaturgic theory of depression. So everybody was so focused on serotonin and the serotonin receptors and then there be what about the glutamaturgic system and that seems to also be involved and ketamine is interacting with another it's a neur another neurotransmitter. >> Okay. It's another chemical in the brain. Yes, another chemical in the brain. Um, but what we're really trying to understand is is it and this is I think with all the psychedelics. So there's you have ketamine for depression and anxiety. You have you know psilocybin also for anxiety and depression, MDMA for PTSD. We're trying to understand is it the chemical interactions of the drug itself in the brain that's making these changes or is it actually the psychological experience that people are having >> that are having these because what the thing is with SSRI you have to take them every day right they have to be in your system to have an impact and when they wear off they're off and you take them again the next day these you can do a couple of experiences and then it has a fundamental shift that lasts and we think that for example psilocybin increases the brain neuroplasticity. So you become more open and more open to suggestion. So when you do that in conjunction with therapy, it's not just like, hey, go out and party and do mushrooms, but when you take them with the therapist that it makes the therapy more stick sticky. >> Well, that's what I was going to ask. Does the setting matter and is there and is the setting stage for the therapeutic effect? >> Yes. So there's a lot of people who are talking about the set and setting and that there's certain settings that have more of an impact. How however this the uh another colleague my Stanford did this amazing study he wanted to look at the effects of ketamine without the psychological effects just the chemical effects so he's an anesthesiologist so what he did he took people with depression when they were going under surgery gave them ketamine while they were under anesthesia and then saw if it had an impact so they didn't consciously know >> they didn't consciously experience the ketamine experience yes but they did have the ketamine chemical >> yes exactly and what he found which was interesting is that it had a significant impact if the people thought they had the ketamine. So it was a placebo effect when the people believed they really had the ketamine there. Actually depression got better. >> So it might just be that this having this you someone tells you look you're going to go in and have this amazing experience. It's going to fundamentally shift your perception is changing. >> Holy cow. >> And that is might be a large part of it is this placebo effect. you have this amazing psychedelic experience and then you're like, >> you know, and so we we still don't fully know >> what it is. But a lot of my patients are in ketamine treatment and they report a really positive experiences. >> So what does this say? Does this say that our thoughts are um just chemicals, right? Is is is we're all just >> I mean this is >> a chemical reaction with a chemical reaction. We are our brains. Yeah. You know, and I wouldn't say they're just that, you know, we still don't really understand this leap from neurochemicals and electrical impulses, you know, firing around in our brain >> um and our subjective experience. And that, you know, Dave Charmers, the philosopher, calls this the the the hard problem of consciousness. The easy problem is if we could map every thought you have and every experience to the specific set of neurons firing in your brain that like the onetoone correlation. Yeah, >> that's actually a really hard problem. But ultimately we could theoretically do that at some point. But even if we did that, I mapped every thought you have to the exact neural underpinnings. Why is it that those neurochemicals firing around create this subjective experience of a thought and that's the that's the you know million-dollar question and that's the hard problem and we might never know >> what can you like when I think about an animal like an octopus that has a more distributed set of neurons >> you know and and I think about the fact of you know we have this neuronal concentration this condensation we call our brain is that even necessary right is it >> is you know I was thinking a while ago about like uh you know why is the head the head? >> Oh yeah. It's not like my son. He's eight. He's mommy. >> Why is the head the head? >> Well, I thought it's like oh here's all the sensors and they put the processor close to the the sensors close to the processor. That's why we have a head. Right. >> Right. Yeah. No, I mean I I never I was never thought about that. >> Yeah. But then I learned about an octopus. They're like, "Oh, they got neurons all through their bodies." And then it's like, oh, there's a brain in the belly, right? There's a stomach. >> We have more serotonin receptors in our stomach than we do in our brain. But it's how they're connected. >> It's how they're connected. >> But but but with an octopus is really interesting cuz they are very intelligent. It's almost like they're aliens. I I come from another planet >> because they evolved on a different line, right? Another different >> They're mollisks. >> Yes. You know, >> so I mean it's so I don't you know there's people like I said with this integrated information theory of consciousness that say consciousness is a property of the universe like gravity. It it exists in any system that has these particular set of you know properties right >> and you know this this distributed like integrated information and so an octopus has it in a different way but it's this fundamental property of the universe that any system could have theoretically. >> Yeah. Yeah. Geez. Holy moly. So, what about what's happening in your brain when you um meditate? And uh why is meditation good for you? >> Yeah. You know what's interesting is that they find that there's some similar patterns of like brain activation and deactivation in the brain when you meditate as there are when you're on psychedelics as there are when you are in creative flow states. >> Oh my god. I was going to ask you about creative flow states. Let's come back to that. Yeah. Yeah. So they're they're very they're similar and parts part certain parts of the prefrontal cortex have decreased activation and those parts have to do with our sense of self >> and it's part the dorsal lateral prefrontal cortex which I've talked about before which is involved in working memory but also has to do with our sense of filtering filtering our behavior to make sure it conforms with social norms. But when you take that filter off in a way when you decrease activation anything goes. There's a freedom and also that's the part where rumination is happening. What are people thinking about me? You know the anxiety, the overthinking. When you turn that part down, whether it's through flow states, psychedelics or, you know, through meditation, >> it it you can't both be in that state and have the rumination at the same time. >> So, it kind of decreases all of those anxiety thoughts. It decreases our sense of self. We feel connected or at one with everything. Time, our sense of time seems to dissolve. And it's really pleasurable to be in these states and it seems to be really therapeutic. Also gives us access to some things that are normally suppressed by that part of the brain into the unconscious. It can suddenly come up, >> right? Because it's no longer suppressed. And that's like MDMA. When people have PTSD and they're suppressing all this trauma, you give MDMA, they're it releases some of these, you know, memories and feelings that are suppressed, but you're in a >> you're doing it within a safe environment, >> right? and in a when your nervous system is calm so that you're able to actually process and work through them. >> Yeah. >> So, but it helps us get so getting these states associated with very positive emotions and and they tend to be very therapeutic and meditation is an easy one. You don't need drugs for it, right? You know, I mean drugs. Yeah. >> It's free. You don't need drug. But, you know, drugs are like a quick like you get there real quick, you know, but not everybody wants to do drugs and I don't think that they should. You know, there's negative, >> especially as you get older, you know, >> and then also not every drug, you know, I was on a panel once about psychedelics and everyone's talking about how great they are, but they're also like some people that have bad experiences, you know, and and are anxious about it and actually some people can get traumatized. >> Yeah. I've known people who've been traumatized. >> Yeah. From these experiences. So, what's a different way to get there? Meditation. Creative flow states. Um, >> but you mentioned the creative flow state. So, I mentioned I was a musician. Oh. >> And sometimes I would uh go into this flow state where, you know, you know, it was the concert type musician, right? >> Where did you play? >> I'm a tubist. >> Oh, wow. >> Yes. >> When I was doing this this concert music, you know, you playing these long pieces and you're reading the music. I would go into the flow state. And at that point, I didn't really feel like I was conscious or even present. >> Yeah. and I'm just everything is just going perfectly and then I come to an awareness of that's happening and it completely throws me off. >> Yeah. Yeah. >> Totally. That's the thing. It's it's um we our unconscious can do much more than consciousness in many ways. Once you've trained the brain, let's say you you've studied the instrument for many years, you know, your brain knows which notes to hit and whatever. Um or like let's say you're a tennis pro, you know, you've practiced many years. Initially, it had to be conscious. You had to think about every way, right? But once it becomes implicit and it's part of your brain, your unconscious can process many more variables. It's unlimited as far as we know than consciousness, which is very specific but limited. >> So, it's almost like your conscious brain is a computer and your unconscious brain is a quantum computer. >> Oh, I like that analogy. Yeah, that's a good one. I like that. It works in parallel in the state state of superposition. >> Super position. Exactly. I like that. But yeah, and so when you let's say you're playing tennis or you're, you know, you think, what angle exactly should I hit this ball? You're going to get out of that flow state because you're turning on these parts of the prefrontal cortex. You're not letting it your brain do what it knows how to do and you're getting in the way. Your consciousness gets in the way. So it's not always good to have conscious. Once you've done all the work and the practice, then you got to let go >> to be in that performance mode. I remember another analogy I like is I was I was hiking with a friend up, we were at Caltech and we were coming down the mountain and I'm like going each step like thinking where do I step next? It's taking me forever and he's like here's this German neuroscientist. He go just run down. I can't do a German accent and he goes just run like your feet know where to go. >> Oh, >> let your body go and do its thing. It knows how to navigate it. If you're thinking too hard about it, it's going to take forever, >> right? >> And he was right. Actually, it was just running down. My body knew all the the physics and the angles of how to navigate to step down this mountain. >> So, and it was like a mountain, but you know what I like. >> And so, sometimes you have to get out of your own way. >> Yeah. You know, I saw that I think it might have been a movie or something, but they were going to ski through a forest and the person was like, "You look at the path, not the trees." >> If you look at the tree, you're going to ski into a tree. >> Right. >> You look at the path. Yeah. >> And your brain knows like you always I once met with this uh like I did this Discovery Channel show where we met all these like superhumans but people who could do extraordinary things and I was trying to figure out how they could do it and I met this like guy who's like the quickest shooter and most accurate shooter. So he had this little like shotgun was down in Louisiana and he could just go and like get all the targets and >> your conscious brain doesn't have enough time to think about it. Yeah. So he said I'm not even thinking about it. I'm already looking ahead at the next thing. my body's doing what it knows what to do and I'm already calculating and looking ahead >> and then it's kind of following behind >> because you can't process that do that in a conscious way. It becomes so integrated in that it becomes implicit and then you got to get out of your way and let go. >> But then when anything you're doing performance, you're giving a talk if you become, oh my god, how are they thinking about me? How am I doing self-aware? You get you fall out of the flow state. >> So you got to let go. >> You got to let go. Yeah. >> Yeah. That's like the something to put on a t-shirt. Yeah. >> You got to let go. >> Exactly. And that's what my book is about. Letting go. How do we let go? >> What is it? Do you have a title for your book yet? >> It's It's the fine art of losing control. It can be good to let go and lose control in a controlled way. >> If this episode gets your brain buzzing, be sure to rate us, leave us a review or comment, and subscribe so you don't miss out on more mindbending content. Your support is not a placebo. It really helps us reach more curious minds and helps us to bring you more great conversations. So, what about creativity? Like, is there a neurological or is that the right word? Neurological basis for creativity? Is there a way to spark your creativity? I'm just going to confess. >> Yes. >> I'm just going to confess. >> Yes. >> In 2022, I was looking to get my second book going. >> Mhm. >> And I was stuck. So I hear about micro doing so. So I go get myself some micro dosage. >> Yeah. >> And it worked. >> Okay. Let me talk about this. Yes. Okay. >> Yeah. >> First of all, I'm very interested in the neural basis of creativity because I'm interested in the neural basis of the unconscious. >> Um because the neural basis of consciousness is one thing, but like I said before, the unconscious is doing most of the work. So what's going on? what's the neural basis of the unconscious and how do we access it in creativity and also myself I'm a painter and I've I studied fine art and did theater so I always want to integrate the science and the arts and what are these flow states um so but the thing with the micro doing is that they actually did research on this and and everyone you know in Silicon Valley and all these tech people like micro doing makes you more creative it actually doesn't >> oh >> so what you had was a placebo effect >> I had a placebo effect or maybe it was just the timing >> or maybe you macro accidentally macro dose because you really got to macro dose to get to the creative states. I'm scared. I was scared. I'm like, I can't I got to control it. I can't. >> But it's not the the actually the micro doing doesn't increase creativity. We see this from studies. So, a lot of it is is anecdotal or maybe a little bit of, you know, the placebo effect. Whatever works works. >> So, I got the placebo effect. >> You thought you told your brain, I'm getting into this state and then suddenly you're in that, you know, and you got you've hit your stride. But um with creativity, what we see is is a pattern of activation. Put people in a scanner. They did freestyle rappers compared to doing a memorized rap or um jazz improvisers doing a piano versus doing a memorized piece. And there's differences in brain activation when you're in these creative flow states or, you know, spontaneous creativity or spontaneous improvisation, whatever you want to call it. Again, you have decreased activation of the dorsal prefrontal cortex. have increased activation of the medial prefrontal cortex which has to do with the generation of new ideas coming from within. So the filters turned down, your sense of self is turned down, but the sort of flow of information and some people say it feels like I'm it's coming through me from somewhere else because their sense of self is turned down, >> right? But it's based on everything, all the input you've put in your brain over all the years, right? All the training you've done, all the whatever you're writing a book, all the information, all the experiences you've had, they're all in there. >> Yeah. But you have to get into a flow state to release that to be able for it to come together in all these new novel ways. >> And so we're starting to see that it's not this the antiquated idea of left brain right brain, right? Like oh your right brain's creative, your left brain. It's not like that. It's really, you know, you get into these different brain states. >> And some people talk about the default mode state where it's just default mode just means what your brain is doing when you're not explicitly focused in on doing a task. >> It's like free daydreaming, free stuff. So to what degree can we have a you know the the a control panel for our brain? So for example >> like an inside out >> right or I was thinking more of the starship Enterprise >> the captain's chair. But I'm thinking about things like okay there are people that feel anxiety like oh I want to turn down anxiety. There are people like oh I need to be creative to create. Oh I need to turn up creativity. Oh, I need to um turn off my inhibition because I got to give a talk or I got to do a performance. Like are there known ways that are not like take a pill, right, that allow you to tune in the brain performance or brain state that you need >> that you want or Yeah. >> Yeah. It dep I mean there's different techniques that work for different people, right? So some people like if you want to try to relax or turn down the anxiety like maybe deep breathing works for you, maybe yoga works for you, going for a walk, talking to a friend. Like it's not one sizefits-all. I think people need to figure out what their particular >> um brain needs >> to get into those states. And once you discover that, then you have your toolkit. >> Right. >> Right. So I just I wish it was like one thing, okay, now do this for that and do this for that. Yeah, >> but because everybody's brain is different, everybody's history is different, the triggers are different, >> you have to what I do with patients is like figure out what works for them, >> right? So, it's sort of like when um I started taking acting classes back in 1999, and there was this thing about being um I forget the phrase, but it it's it's learning yourself, right? It was like, okay, the idea of acting is not to act, but to literally be. And so if when you're in um >> life and you experience an emotion, >> Mhm. >> recognize that, stop, go in the mirror, and do it again so you know what you're like when you experience that emotion. So you can be that. >> It's like method acting, right? A bit like figuring out what you're Yeah. >> Yeah. Yeah. Yeah. Exactly. So it's not Yeah. Right. So I forgot where I was going with that. >> Yeah. >> Just be in the moment and be who you are. Well, I think you know we're each all of us. Oh, that's the thing. You have to you have to become self-realized is what they called it. Self-realized. So, this is another >> sort of way of becoming self-realized. One has to in order to manage your own mind and consciousness and feelings. Then you you you have to make that connection between what so I'll give you another example. >> One of the most difficult things a person has to go through is getting over addiction. That is a huge brain thing. And there's different types, right? So there's heroin addiction, which is physical. Then there's something like cocaine, which is more mental habitual. Well, I went through that one at the age of 25, right? And um >> cocaine one. >> Cocaine. Yeah. And I went to rehab and what they told me did not do anything for me, right? I I did everything they said to do, but what I heard the other people talking >> and I found my answer. And what it was was the drug, you know, would come to me in my dreams. it would talk to me and it would tell me how good it's going to be, you know, and all this and and I was hearing what everyone else was saying and I put together a sentence that worked for me. And that sentence was, "If I do it, I'm not going to get high, I'm going to get low." >> Right? And that's the sentence I said to myself because it took five years for that voice to leave my head after I completely stopped. Right? And that sentence is what I would say over and over. Yes. >> Right. Every time it tried to lure me back in, right? Yes. And so I if you do behavioral therapy >> and there are people that you know are trying to achieve whatever mental goal they have, how do you get to their self-realization? >> You so especially with um addiction. So what you did there like your technique was aversive conditioning. So basically you associated in your mind you made a new association instead of drug equals good and high drug equals bad. Yeah. And it took you a while to make that become an implicit association, but you kept repeating it, repeating it, repeating it. Drug equals I'm going to feel bad instead of drug equals I'm going to feel good. And once you start pairing a stimulus with a >> punishment or something negative, then you you unlearn you changes your behavior. That's called adversive conditioning, >> right? So, so like with cigarettes, you say, "Every time you were trying to quit, every time you take in an inhale, I want you to think about the cancer coming into your lungs and infecting your body with black whatever, whatever." Give them some sort of image that there every time you take a puff, that's what I want you to imagine. Every time then you start toversive conditioning it become or when a kid gets caught smoking, you say, "Now you got to smoke this whole pack. You can't stop until the end." They get sick. They never want to look at a cigarette again. Right? You're connecting the stimulus with something something bad. But the way to get to people with with addiction is something called mo motivational interviewing. So you there's a way of interviewing a person to get them to figure out what motivates them. >> And then you got to link that thing to something like like let's say you say to me my kids are the thing that means the most to me whatever. And you start associating well if you do these drugs like >> you're gonna lose your kids or you're gonna and like that's enough to motivate them. But external motivation does never works as good like like telling someone you got to study because you have to get a good grade on this exam is not going to motivate. They need to be internally motivated. You need to see what they care about, right? >> And then link it to that. So maybe my kids like I want to study because >> I want to get into a good college. That's really important to me. Or I want to study because I want to get that new bike and I know if I get this good grade, I'm going to get that new bike. whatever it is for that person, find out what motivates them and then link the behavior to that and they'll be more likely to stick to it. >> So, is there a there's you talked about two there's the motivational side, there's the averse aversion side. >> Yes. >> Is there one that works better than the other or do you cuz let let me say when I am a mentor >> Yeah. >> I find that you know there are some people that need a kick in the pants that need to be challenged and there are others that need to be lifted up and encouraged. Right. So how do you you know find >> it's not again it's not one sizefits-all like there's different theories in psychology about oh you know this kind of conditioning works better than the other but really it depends like there's like I think aversive conditioning is great there's because there's what's called one trial learning from an evolutionary perspective it's adaptive if you if you ever notice if you eat something you get food poisoning >> you don't want to go near that ever takes one time one time to learn you don't want to go to that or you don't want to go to that restaurant again you got food poisoning there I did it happened to me Right. >> Right. When I moved here, I ate a Cobb salad with some raw chicken, got food poisoned. I haven't been back to that restaurant. >> Right. And of course, that makes sense. Adaptively, you're in the foraging of the forest. You find you eat a berry, you get sick from that berry. You got to know never eat that berry again. You're going to die. >> What' you call that? One something. >> One trial. What did I call that? >> Yeah, that was it. Yeah. >> Yeah. One trial learning. You You learn it from one >> one experience, right? >> And it's after that you'll never do it again. That's what aversive you know how powerful >> an aversive experience can be to change your behavior >> and sometimes it takes a little longer to get there through the kind of reward pathway >> you know so there is there is debate in literature of like you know with children what's the best way do you punish them or do you give them you know motivate them with incentives and rewards and it's kind of a combination of both and you see some things work better than others you know like my son's really difficult because he doesn't punishments don't seem to affect him. If I say, "Go to your room." He's like, "Okay, fine." He goes to his room. He starts coloring. He does. He He makes the best of it. He doesn't. >> He's not bothered. He's like, "Sure, I'll go to my room. Whatever." And like, I'm like, "Damn it. What do I have left in my tool kit? The only thing I have left is the iPad. You can't have the iPad. You know, that's it." I'll tell you this one thing like an anecdote. My grandmother who did large amount of raising me, >> I was a teenager and I was going wild and you know, misbehaving as one does, >> right? And I got caught one night. I I snuck out my house. I got caught. It was bad. >> And I was like, "Oh god, I'm going to get real punished now." >> And she comes in my room and she just says to me, it stuck with me to this day. And now I have a daughter who's 11 and starting to roll the eyes and stuff. She said, "I'm going to just say this one thing to you. I'm not even going to punish you." She said, >> "I am just going to say to you, I hope that one day you have a daughter who is exactly like you." >> And then she walked out and closed the door. I get chills to this day cuz I thought about that and I was like, "Oh no, >> that's terrible. I don't want to be that." You know, that made me start to change my behavior. That worked for me. But now I have a daughter and I'm like, "Shit, I hope my grand curse I hope my grandma is the hex. Did she put a hex on me? Please don't let her be like me. Please." >> Well, you know, I my son turned out to be like me in some ways, and it really allowed me to forgive myself. >> So, I was like, "Oh, it ain't me. It's genetic. Right. Right. It's about me. I couldn't help it. My bloodline. There's nothing we could do. >> Right. >> Yeah. But it's it's a scary thing. So anyway, different things work on different people depending on their psychology. The same thing with learning and education. Like some people want to really have their handheld throughout the educational process and have like lots of testing and they really need that. Other people want freedom and they really thrive in that kind of environment. Like when I did my PhD, I was in the UK and at Oxford, they let you kind of do your own thing. Some people drowned in that because they really needed they came from America. They were used to the structure and needed those um like benchmarks. I loved it, you know, but everyone every brain is different. >> Oh man, I'll tell you. So in my case, >> the last thing I want to do >> is what someone tells me to do. >> Right. Right. That's the thing. So for a person like you, give you freedom. >> I'm an autodidact. Right. Yeah. I Yeah. I'm self-driven. >> Same. Right. But for some people who aren't like that model works for self-driven people like and you know I didn't like people telling me what to but some people they aren't self-driven. They need to be told look you have this deadline you have to have this year and that works >> and they th they thrive under that. Yes. Yeah. Yeah. So fame and the brain. So let me give you another I know you have some thoughts on that. And so let me just tell you my personal experience. >> So you know I started doing science television >> about 13 years ago and now people recognize me and it's completely changed the way I move through the world. Right. It doesn't make me have a big head or anything like that. >> It gives me a comfort because, you know, I grew up in great violence, you know, common violence, you know, and then and I came of age and I turned 18 in 1985, the crack cocaine era. Anytime you went out, somebody was mean mugging you, right? I got I was at gunpoint so many times for because of the way I was living my life, you know, various things like that. But I just have this I was just going through the world on the defensive all the time, you know, on edge, right? Always looking. >> But now I expect that people are going to greet me in a positive way, which is kind of new, >> right? And what it's done is it's really just been a relief, right? It's just a >> Yeah. You know, on the defense, you don't think you're being attacked. >> Yeah. Yeah. So I So it hasn't taken me from like, yeah, I'm the man now. I don't feel that at all. Right. I'm still just the same dude. But I Wow. I do feel such a sense of relief. >> Yeah. Not a threat then. >> Not a threat. Yeah. Everybody's not a threat anymore. >> Yeah. Yeah. >> Yeah. I think, you know, I So, I I I've gotten really interested in how fame affects people and it's >> it's not one sizefits-all. It's very different depending on the So, so I'm really interested in how different personalities intersect with this phenomena of faith. And if I can interject, >> yeah, >> you know, there's the phenomenon of children who become famous and how negative that can be in their lives. So, do you differentiate between adults and Yeah, >> there's all different types of fame. There's childhood stardom, right? That that affects the developing brain. You know, suddenly you're having this really abnormal experience and all these sick events. You can have anything you want and your brain isn't even fully developed. You don't even have impulse control. Like a lot of bad things. If you don't put things in place to help them, it can go really south and we've seen a lot of cases of that. You know, you have fame, you have infamy, being famous for doing something. You know, you you get famous for just doing living your life and you do something amazing and then you get famous. You have a sports an athlete is just trying to do their you know actors, politician, there's different types of fame. There's falling out of fame, you know, getting disgraced, getting cancelled. >> Well, I'm really interested in the psychology of this. Why do people chase it? Why do they want it? What's the evolutionary roots of it? Right? >> Like what what we see from studies is that actually the person who has the best advantage is not the alpha, but it's the beta. It's the best friend of the famous person. It's the right because everyone wants to knock the alpha person off the thing. They're constantly having to worry about can I keep this and threats and people want to knock them down. The guy just next to him, the best friend is getting all the benefits of, you know, the, you know, more chances to procreate and getting more resources and getting all of that and getting all into VIP clubs, whatever. Cuz like, you know, when you're Jay-Z's best friend, you're getting all the good stuff, but you're not getting all the people digging at you and trying to knock you down. >> Yeah. You're famous, but free, >> right? Exactly. So, fame comes with a lot of perks, but it comes with downsides as well. Um, but but evolutionarily now we're in this really weird world where anybody can sort of be famous and everyone thinks they're this close to being famous, which it's elucery. It's not true. Like it's, you know, internet fame isn't really what we meant by being famously sustainable or for having done something amazing in the world. Like, you know, we're all going to know >> whoever, you know, as the person who walked on the moon for the first time or Miller had or whatever, right? Like they did things that that's why they're well known Einstein, right? But now it's like I can create a meme and like suddenly but that doesn't last long and then you get the dopamine high. Oh, people like me, you know, and then you're seeking it. Oh, for more and more and more becomes like a drug. So, we see the same neuroscircuitry involved in drugs of addiction. >> Oh, >> are involved. It's involved in fame. It's >> about formerly famous. >> Formerly famous. I mean, like people who've been famous and fall out of fame. So, there's different types. Some continue the rest of their lives searching to try to get that high back again, right? It's like you got a cocaine high and now you're just keep trying to get back to that high. The successful people who navigate that find some other meaning and meaningfulness in life, >> right? Like they become an astrophysics or they become like, you know, and they find other meaning. Other famous people find meaning in now I'm going to do something positive with this platform or with this fame that I've gotten and I'm going to turn it into something good for the world and that becomes reinforcing for them. You know, you get dopamine from helping others. You know, you bring up this another point implicitly >> that seems to track to all sorts of positive benefits, right? Like longevity, being healthier, and that is living with purpose. >> Yes. >> Right. And and and and one of the sort of um conflicts I have with the way we talk colloquially, you know, we talk a lot about being happy, right? know if I'm happy. And and when I reflect on my own life, you know, it hasn't so much been happiness, but fulfillment, right? And and one example is um uh I would when I was in the military, you know, sometimes there would be some screw- up we've all participated in. So, they're going to punish us. So, they're like, "We're getting up at 4:00 a.m. and we're going to run for 6 miles." And you know, when we wake up at that ungodly hour and we're trying to fall out and it's a chilly morning, we're all complaining. >> Yeah. >> But at the end of it, we're all like, "This feels great because they just showed us what we were made of, right? They just extended us and pushed us and we lived up to it." And I find in those situations where I'm just drugged and I persevere is some of the best >> feeling I have. But I wouldn't describe it as happy, >> right? You know, it's the same thing with, let's say, having children. >> Having children doesn't make you happier, right? >> Dr. That's the one thing that's come out of this. Cut that one. >> She says, "No, but you know, you're not sleeping. You're I mean, I'm like their personal servant, you know, put the you didn't make the pasta the right way. Make it again." You know, you're driving them around everywhere. You're not increasing your level of happiness, but you are increasing your fulfillment, right? There's a joy you get from from hardship and adversity because you're doing something that has meaning and purpose like I'm helping this human who's going to like, you know, grow into something in this world and that becomes my purpose and that has meaning for me and every interaction I have with them is valuable. And so yeah, happiness, you know, it's >> so what's happening in the brain when you have fulfillment and meaning and purpose and and why is that so beneficial? >> It's different than so there's highs you get in life, right? From like a a amazing peak moment, which is great. And you know, a lot of patients come in like I don't know, I don't feel happy. It's like it's not about happy. It's about >> can you just It's like equinimity. >> First of all, that's first and foremost. Your baseline should just be I'm at peace. >> Right. Hopefully. Hopefully. >> Yeah. Right? No, most people aren't and that's what we're just trying to get there. You know, it's not about, oh, I want to be happy. Those are peak moments. You can't always be happy. >> So, that's first and foremost. But our brains in some ways give us a reward or give us some certain types of pleasure from finding meaning in things. So, like when you solve a puzzle, >> that's a good feeling. Yeah. >> Right. you like and and there's evolutionary reasons for why our brains evolved to find pleasure in solving problems and and I think finding meaning in in ambiguous things and finding purpose >> it gives us a sense of this pleasure this contentment right >> which is different than the high the the big dopamine highs and the rushes like a drug or fame >> so what what is it inside the brain is it turning things down >> it's hard to say it's not necessarily really turning things down. But the when I think people are fulfilled or feel at peace or um have a sense of purpose, you do get some dopamine. You get the serotonin which is the more >> long-term feeling of ha of sort of a happiness or contentment. But it is turning if you want to say turning down those anxiety parts of our the rumination the the you know obsessing over all the negative things. When you're like you know these negative things are happening in my life. It's really a sense of resilience. But I have purpose. I have meaning, >> right? >> It helps you build up this resilience and we see that there's a genetic component actually to resilience really. So there are people like let's say who've been they look at studies with PTSD same talk about being in the AR you know in the military. You go to war they looked at soldiers who went to war both experienced the same horrible things. A certain subset goes on to develop PTSD and the others don't. What's is there something neuroprotective? And it turns out there is there's certain genetic differences that help make people more resilient. People are studying this now. How do we increase resiliency? But the point is that when you have a purpose or meaning in addition, let's say there's some genetic components, but it can help inoculate you against all these negative things that inevitably happen in life. People die, you lose a job, whatever. That all happens to everybody, >> right? >> Some people overcome it because like I have a greater sense of purpose. Some people find that in religion, right? Some people find that like I have a higher purpose. When people go to AA, they always say find a higher, you know, >> but it's something greater than oneself. >> Right. Right. Right. >> It's like that kind of feeling. It's not just about me and my little petty problems, whatever. It's something greater purpose. And when I think when you link that >> yourself to something bigger and that's what I talk about as a cure to kind of fame. It's not about me me. I need all the agilation and the likes and whatever. It's >> what's your greater purpose outside of you, outside of yourself. So what do you think is coming down the the the pipeline as you know as we study consciousness as we study the brain what are the frontiers right now and what are going to be the next breakthroughs that are going to occur and let me just uh add a little bit you know I've become aware of computer brain interfaces and you know all that kind of stuff so be as broad as possible >> yeah I mean that's that's exactly what I was thinking of and you know is this idea of us merging with technology in a way of having neural implants and neuroprothetics and you know implanting devices that we merge with AI right and that might be the next step of human evolution is that we become cyborgs >> that sounds cool >> I think like well look it's happening anyway these technologies are being developed to help right now it's to help people who have disabilities or for you know it's for mental health issues or neurological issues Parkinson's, these kinds of things, right? It's helping people, people who are um paralyzed and now they can put these implants in that >> translate your thought about moving a limb to a computer that then controls a prosthetic limb that will move it with your thoughts. So, you think I'm going to pick up this cup of coffee and you can do this with the neural implant. So, it's giving people, you know, it's having a great uh it's helping people who are disadvantaged. >> However, it is of course going to move into this world of cognitive enhancement. where people are like, "Well, what if I have a neural implant that can make me, you know, smarter or have more pay more attention or, you know, help modulate my emotions in a certain way or control my desire to want to eat this fatty thing or whatever. We're going to start >> re as we've done with other technologies is, you know, like you were saying before of like mental engineering, >> right? >> We're going to like human engineer our brain." And people are already starting to do this. I think ultimately either it's going to be have like performance-enhancing drugs will have to be completely outlawed that no one can have it because it will give people such an advantage. They'll be the halves and the have nots. >> So either everybody has to have it >> or nobody or it's going to be amazing. >> Once the cat is out the bag, those with resources are going to >> of course and it's all the tech and the Silicon Valley people are going to start having this. So I think we will start merging with technology in this way. Things will get smaller and smaller and smaller. You just say mom and it conversations in your head. But then the question is going to be and this is what I gave a recent TED talk about was like what does it mean to be human then? >> What does it mean to be human in this world of evolving technology and AI and as we're merging with it >> and you know this classic silicon chip thought experiment is like if you replace one neuron with a silicon chip are you still you? Are you still conscious? then another then another another at what point are you still human what point are you still conscious what does it mean to be human and I think right now our last like like AI >> artificial intelligence maybe you call it advanced intelligence or you know enhanced intellig it's already >> smarter than us in many ways it can do things way quicker than us it has access to all the information all the books and >> so what's left for us I think is consciousness at least for now >> and that allows I think AI will we'll be able format out the stuff we don't want to do. Well, answer emails and bureaucracy and all this stuff. Let them do it. Save us time and allow us to be more human to get back to our evolutionary roots because we're still cavemen brains in a modern world. We want to just like hang out with each other, listen to music, you know, what procreate, like eat, right? So, you know, go on vacation, go to the beach. So, we can have more time being human, being creative, doing what we want to do. >> Sounds like the world of Star Trek. >> Yes. >> Right. Yes, >> we've eliminated greed and right >> all the need for that kind of stuff. >> But I think that's the future. I think we're going to merge with technology. And I think um at least right now in psychiatry, you know, a lot of the psychedelic psychotherapies are on the cutting edge, but this really thinking further in the future is merging with technology. And I'm hoping for a utopia. It could be dystopic >> at this. What about brain health? >> Brain health in terms of >> Yeah. Like like there are people >> like longevity or >> Well, well, no. Like we were talking about the the therapy with the because people have you know schizophrenia and >> right >> various brain conditions >> I think ultimately with that and things like Alzheimer's and what not I mean our our limiting or rate limiting thing is our understanding of the development of these diseases but once we have that understanding which I think AI is helping with scientists now to understand these things >> ultimately I think we're going to go back to like crisper which is like >> modifying yeah the gene genome so that these diseases never develop cuz now we're catching them already when it's too late. Once you have like let's say the visible clinical Alzheimer symptoms, you're already so far down in the disease process, it's very difficult to res reverse that. All you can do is try to slow it down. >> But if we can start with the genome, >> yeah, >> ultimately and there's a whole bunch of ethical issues around this, right? And there's people who argue like with autism like I don't want you taking away this this autism is something, you know, it's a gift and right? So it becomes these arguments that >> but ultimately I think it's going to come down to modifying the genome to get rid of you know some of these >> dis. What about um could you imagine militaries like getting rid of fear in soldiers for example? >> Oh yes. >> Oh yeah >> definitely. Yeah that's for sure. >> Not saying I'm doing any work with the dot but >> Oh no. >> Yeah. Yes. For sure. I mean and there we know like from neuroscience we have a pretty clear understanding of the fear network in the brain >> and for sure we can do things like shortcircuit that fear network and get people to be you know not afraid. >> Wow. So if you look at the what's next in terms of our understanding of the brain you think AI is going to be a big part of getting us there? Absolutely. And you know talking to some of the leaders in in the in AI and you know the head of anthropic and other places who who was a computational neuroscientist by training you know we were talking and like we knew the same he knew my mentor and whatever >> you know he was saying he started this got into AI because the brain was so difficult to understand you needed new ways in which like the computational power and things to understand it but I think with you know what I'm seeing with what's happening with AI is just giving us greater power to be able to understand these complex lexity of the human brain and I do think that there's some hope there that we'll have a greater understanding and what we do with that understanding and that information is another >> TBD >> yes it's like with any great with great power comes great responsibility right so it's about the decisions we make like nuclear power could be really great or it could really suck so >> that I'm trying to remain optimistic and hopeful but I do think AI is going to be a huge you know component what transforms our understanding of of the brain >> yeah what I what I tend to see is that when we make these creations that have built within them the capacity for great good and great bad. You end up getting both. >> Yeah. >> Right. But it it it you you want to control those bad, but you know, and and reap the good. >> Do you know what it really I think it comes down to? It's it's Freud because we are humans, these sort of you know, ape-like creatures roaming around with all these basic instincts. And you know, Freud talked about we and not everything Freud said was, you know, he was out there on a lot of things, but certain things he got right. And that we have this either this death instinct, you know, this instinct to kind of it's our dark side to like kind of toward killing ourselves basically, >> or this other instinct, which is the like life instinct and libido. >> And it really depends on >> human instincts and where we're going to go with that. I think ultimately we're going to develop these technologies because we have the cognitive capacity to do so. and it's going to lead us in all these different directions. But do we have the dark kind of death instinct or is that instinct for life and survival going to you know overcome and that we don't know. >> I tend to be a half glass full guy. I think that, you know, our species has already been through so much and we tend to catastrophize the modern time and we tend to think about us all dying at once, the end of the world, even though we know we're all going to go individually, right? Why be concerned about when we all go at once? So, I think that, you know, I I have faith in humanity that, you know, we might have our ups and downs, but the arc of knowledge tends toward increase, >> right? And >> and we are and there there's this book the um you know that's saying basically the moral ar like we are getting we are getting better >> right >> in terms of our like life quality of life and all of that you know there's less murder than there was and there all these by all these metrics we are getting we are getting better >> you know ultimately I guess at some point the universe is going to like you know yeah 10 to the 68 10 to the 100 years >> but this is my only my only complaint is that if we don't go back into this stream of consciousness or I'm not alive for infinity according to what was that thing the infinity like uh we're alive constantly always >> oh yeah eternalism >> yes eternalism >> I just want to know how the story ends >> I get this glimpse of everything that happened before >> and or at least that we know of from history and what's happening in my lifetime but like how does the story end >> you want to get my next book >> oh okay does it tell me the answer >> yeah the title of the book is why do we exist right >> the nine realms of the universe that make you possible One of those realms is the temporal realm. And I go up through the past using a set of principles, you know, framed it in a physics context in a in a non-standard way, right? >> And then I go through the future, >> right? And uh you know, I paint the picture of of what's to come based on all >> our current knowledge. And it is it is different. I think it's a different take. I I think that you know, I'm I'm giving it in a different way. It it can get kind of lonely. >> Okay. But only at the galactic scale, right? On the individual scale, feel better. >> You know, given our ingenuity, we're we're going to be able to last much longer, I think, even than our son. If uh even in the planet, we we can last longer than planet Earth can. >> Yeah. But we're going to be different. Like you say, what does it mean to be a human? If we did no integration with >> technology a million years from now, we'd be >> Yeah. >> Probably as different as we are from a million years ago, right? >> Yeah. We have to in I think we have to integrate with technology in order to survive. >> Well, I already have. I have a titanium screw in my shoulder. >> Oh, there you go. I I don't have any such thing, but I will. It'll make >> You're going to be You're going to have your brain. >> Yeah, I'll do whatever it is, >> Miss Heather. Dr. Heather, >> you have been amazing. Thank you so much. I've learned so much from you. I expect to uh receive a diploma now that you've >> educated me. Do I get a degree in neuroscience? >> We can talk about it. >> Yeah. appreciate you coming. This was excellent. Thank you so much. [Music] [Applause] [Music]