Kind: captions
Language: en
your Ted Talk which of course has been
viewed by millions of people now there
was a really interesting slide towards
the end where I I I very much resonate
with this idea what's the root cause of
multiple diseases can we you know
address the root cause and then you know
we're we're automatically going to take
care of multiple different Downstream
consequences and that was a very
powerful slide showing that when
angiogenesis is working well or when
it's not working well what can happen in
the body could you just talk us through
um through that lens and geog Genesis um
because I think that's really
interesting and then you also mentioned
cancer and blood supply and again could
you just talk to us about cancer and how
it can only grow to a certain uh size
unless it gets its own blood supply as
well
please yeah sure our
circulation is uh uh these blood vessels
this network and the blood is really the
vehicle that carries oxygens and
nutrients and everything else that our
cells need to survive so when we have
the right amount all of our health all
of our organs are functioning
properly um sometimes we need a few
extra blood vessels so you're working
out and trying to build your muscles
when your muscles get bigger it requires
more blood vessels bigger blood supply
no problem your androgenesis system can
actually Supply and help to grow more of
those blood vessels but they keep it in
proper volume so not too many not too
few blood vessels very important
principle of angiogenesis that's Health
we have good circulation now here's what
happens in disease when you don't have
enough blood vessels what are some of
the typical diseases that occur when you
don't have enough blood flow well one of
the things uh is um after a heart attack
if you cannot grow enough blood vessels
you parts of your heart will get weaker
you can get heart failure and and you
and a heart attack can actually be even
fatal if you don't have if you have
inadequate blood vessels to try to
bypass any temporary blockage same thing
as a stroke we know after there's a
stroke uh sometimes a clot gets sent to
the brain and results in that type of
stroke your uh angiogenesis defense
system uh is uh scrambled to be able to
immediately generate bypass tiny little
bypass vessels get around that blockage
to save the brain beyond the blockage if
you can't get enough blood vessels
growing in that situation parts of your
brain die and um and you wind up being
paralyzed or having deficits after a
stroke um in diabetes uh many people
with diabetes lose their legs they have
their legs amputated mostly because they
have problems healing wounds on their
feet now the reason is because they
their nerves actually become they go
numb their nerves die back diabetic
nephropath neuropathy and the reason
that the nerves die back is because
there's inadequate blood vessels feeding
those nerves so now in diabetes some of
those nerves and your feet and your even
your fingertips actually are don't have
enough a blood supply they die when the
nerves die you can't feel when you Ste
on a pebble and you create a little hole
that hole gets infected that wound now
also won't heal because it doesn't have
enough blood vessels that's an example
of inadequate antien and cause a problem
and so now Medical Treatments actually
have been designed to actually try to
stimulate more blood vessels to coax
more vessels in where they're needed but
foods can also help do it as well on the
flip side when you have too many blood
vessels and this is where cancer comes
into play it turns out that we all have
cancer in our body I mean cancer is We
Fear everyone fears cancer the the word
actually you know causes a shiver to run
down most people's spine everyone knows
somebody who's been touched by cancer
and I would say most people know
somebody who's died of cancer actually
and so this is actually one of the most
fearsome
diseases but yet biologically we are
actually all forming cancers in our body
all the time because all it takes for
our 40 trillion cells to do is to make
those little mistakes I told you 10,000
mistakes are fixed every day a few of
those going uh kind of getting stinking
through will turn into a microscopic
tumor microscopic cancer and this is
called cancer without disease because a
tiny little M nant cancer can grow up to
the sze the tip of a ballpoint pen and
then it's
frozen like a pimple can't go any bigger
because it doesn't have a blood supply
no oxygen no food nothing to feed it and
so those little microscopic cancers sit
there until our until another one of our
defense systems our immune system Wings
by like a cop on a beat and sees this
abnormal cell sitting on that street
corner in a good neighborhood and then
says get in the car we're taking you
away and so our immune system destroys
these microscopic cancers but some
cancers are able to some microscopic
cancers are able to hijack our body's
regular androgenesis defense system and
selfishly grow blood vessels to feed
themselves now I worked in a lab
studying agenesis and we discovered that
once an avascular or bloodless
cancer is able to get vessels to touch
it the moment that that touches that
cancer can grow 16,000 times in two
weeks so literally angiogenesis out of
control is a trigger uh an explosive
trigger for tumor growth and in fact we
know that if you can cut off the blood
supply or prevent tumor from growing
their blood supply you can actually keep
these cancers harmless for long periods
of time and so this is what foods are
able to do foods that inhibit
androgenesis they won't they won't stop
the good blood vessels from growing
because good blood vessels are actually
solidly locked into your body your your
defense system ensures you're not going
to get rid of your good blood vessels um
um with food but those extra blood
vessels tend to be fragile those are the
ones that that that the foods that we
eat and then if necessary drugs that we
can prescribe can really just kind of
Shear those extra vessels away yeah this
whole sort of field of angiogenesis and
blood vessels I think is going to be
fascinating for people because I think
many people you know everyone's aware
that they've got blood vessels inside
them I think a lot of people will think
yeah I I sort of learned this in biology
at school that there's a heart and it
you know the blood vessels it pumps
oxygen around the body that's how oxygen
gets to all my muscles and organs but
potentially it kind of ends there like
it doesn't go beyond that and what what
I love about that explanation is when
angre Genesis is not working well we're
not able to make new blood vessels where
we need to it can cause a whole
multitude of different diseases but also
when it's kind of out of control or gets
to these cancer cells too much
angiogenesis can cause
problems and and therefore the question
for me Dr Lee is if angiogenesis sits at
the heart of multiple different
conditions so we can look at it as a
root cause we also say similar things
about chronic unresolved inflammation
don't we we talk about inflammation
being a root cause of lots of these
chronic diseases so can you speak a
little bit about the relationship
between inflammation an anagenesis
because it strikes me that they can't be
separate they they probably sit side by
side together in most cases yeah know
it's such a great question I actually
worked on Research exactly looking at
that inter relationship wow so we know
well let's let's take a look at just
sort of something everybody recognizes
and to show how inflammation and blood
vessel growth are go hand in hand uh if
you um are in the kitchen and you
accidentally cut you're you're you're
cutting a piece of fruit and you
accidentally cut your cut your finger or
cut your hand what's going to happen
it's going to bleed all right now so
you're going to stop the bleeding then a
few minutes later you look at the cut
what's going to happen it's swollen it's
puffy it's red because inflammation's
actually gotten there your immune
defenses have sent these inflammatory
cells these are the kind of super
soldiers from our immune system that go
there to kind of clean up um and prevent
any bacteria from rushing into that site
um and then shortly
thereafter within a day or so um new
blood vessels start growing because in
the inflammatory cells the cells from
your immune system started to release
some signals to say hey you know what
we've cleaned up it's time to reset the
table and so now blood vessels actually
start to grow into it so in inflammation
sends the signals for wound healing for
healing that for blood vessels to grow
by the same token inflammation then goes
away which is why our wounds don't stay
puffy the whole time the puffing redness
goes away the blood vessels grow you get
a scab and before long you're back to
normal and that's because both
inflammation is turned down turned off
like that's that car volume of the car
radio and also androgenesis once you get
enough it stops and so this is getting
back to that set point now what happens
when you actually have chronic anything
usually it's not a good result so
inflammation being really good a little
bit is really good so you know I think a
lot of people misunderstand like I want
to get rid of all the inflammation in my
body no you don't because you want the
ability of your body to be able to mount
small amounts of inflammation when
needed for a short period of time and
then to go away all right that's that's
you want that that's life saving but
what you don't want is for that inflam
to get there and the volume to keep
turning up up up up up or that it never
gets turned back down that's chronic
inflammation and that's abnormal so your
body this whole idea of turning up and
then turning down um the volume for
inflammation if you don't can't turn it
down the inflammation continues to
smolder in your body example I've given
is sort of like for anybody who's
listening who's enjoyed going camping
yeah you go into Woods you set up a tent
it gets cold at night what do you do you
build a campfire and and that's like a
little bit of inflammation gives you
warmth it serves its purpose and you
know when it's time to go to bed um you
know you either let it burn down and you
just you know make sure that um it's all
walled off and you're fine but that fire
if it doesn't um burn down but actually
spills out and catches the forest on
fire now you actually got a problem
because now this thing is going out of
control control in diseases with chronic
inflammation like lupus like rheumatoid
arthritis um like diabetes frankly uh
you wind up actually having this chronic
inflammatory state that starts to
provoke all kinds of other things and
remember we talked about tumors and
anagenesis well if a tumor is kind of
like a wound it can hijack blood vessels
and you got inflammation and now the
cancer itself causes some inflammation
you're just making a a hell of a lot lot
easier for that tumor to get a blood
supply which means that the cancer is
more likely to grow and in fact we do
see this in patients patients who are
actually chronically inflamed we know
that inflammation is one of those
Hallmarks for people who develop cancer