Transcript
Uz2lCTUy400 • Stay Young Forever: What To Eat & When To Eat To Fight Cancer, Disease & Aging | Dr. William Li
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Kind: captions Language: en the evidence is pretty overwhelming that if you drink green tea regularly even a single cup but ideally three to four cups of green tea a day and if you you know my great uncle who lived to 104 um he drank probably six maybe 10 cups of green tea a day um was healthy until his very last breath and um it's been shown that actually drinking green tea regularly lowers the risk of colon cancer lung cancer breast cancer brain tumor and so there's a lot of evidence human evidence that actually shows that to be true um Tomatoes been shown to lower the risk of prostate cancer we talked about that um uh and eating um good phytonutrient rich green vegetables um also been shown to be protective against a whole flotilla of different types of cancers and so one of the things I talk about in my book and again it's you know this is like a deep dive into this is well how much should you eat how many servings do you need to eat a week or if you eat seafood um like what type of fish and how often and how much fish should you eat a day I'm I'm somebody like because I came out of the you know the biotech world you know like it's all about the dose right and actually I think you know one of the famous uh uh a Greek uh philosopher is basically saying you know the the poison is in a dose anything that's too much or too little it's going to be not enough or too much and so um one of the things I've tried to do um over the course of the last year here frankly during the pandemic I spent a lot of time thinking about how do I take a lot of this information that's been bottled up that like led to me to write the book and get it out to people so I actually created an online course and I do master classes now to really get at those sort of nuts and bolts of details um of of of of things but um uh so I would say follow the evidence there's certain foods like green tea like tree nuts like tomatoes like leafy greens like seafood and and there's specific types of seafood um you know it's not just salmon um but even shellfish actually and heck and hche and some of these other things that consider so again if you if you only listen to the sort of the common Urban mythology you hear the same things eat your salmon eat your kale you know uh and and and it goes so much deeper than that like you you know you you prompted this a couple of times you know is it as simple as it's never as simple as the God is always in the details and those details allow us freedom to choose the things that we might like it gives us more of a repertoire to go into yeah I love that speaking of details I mean we've had we've had other researchers on the podcast and they talk about you know these really intricate details of our physiology igf-1 uh mtor insulin do you I mean do those come up at all in your recommendations do you talk about you know minimizing glycemic variability with your dietary choice do you talk about you know keeping insulin low not spiking it with you know uh too many eating the consumption of too many carbohydrates added sugars and things like that or is it more big picture for you just you know prioritizing food quality which is here's the thing which is what what it sounds like to be well here's the thing I'm a researcher so I am into those details the glycemic inexs the CRPS and all these other things that a lot of people talk about but when I actually try to communic unate to people who are really interested in changing their lives for the better just want to optimize their health they don't want to be told they don't need to know all the they they want to feel more empowered and so I try to kind of um up my own game by trying to simplify the details into things that people can use like and if you want to have that convers you know like if one wants to have that conversation about the tomatoes and how do you cook them and what happens to the chirality the lopine molecule we can get into that stuff but look I just told you if you're a man and you want to lower your risk of prostate cancer tomatoes are great two to three servings half a cup each time if you cook it it actually makes it a little bit better for you and if you asking me what's the most potent tomato that I should choose from I would say San Marzano Tomatoes actually have the highest amount of lopine um and and you know like I I like to actually message in ways that make sense to people that are really practical but absolutely put me in the Olympic ring and give me an ape and we can fence and go into all those details I love it were you a foodie before you became uh a scientist like when when did those for you converge you know I first of all grew up in a background my as my background is Asian but I grew up in America I was born here and you know I I ate a lot of Fresh home-cooked Foods with fresh whole plant-based Foods all the time um it was a treat when I had a sloppy joe was a very rare day when I had a lasagna or whatever it was I mean I I used to covet like you know those things like oh man my friends are having all this great stuff but I I really grew up eating a plant mostly a plant-based um Whole Foods uh diet um but I I also grew up in a family and with friends who really enjoyed eating and so um uh when I went to college I Lov to explore foods and a lot of people don't know this but um I uh I enjoy cooking uh and if you you in order to enjoy cooking to in order to cook well you have to love to eat like to eat and when I when I finished College I did a gap year before I went to medical school and I actually and this is you know I hate to say it's like 1984 I took a gap year and I went to Europe and where did I live I lived in Italy in Greece why specifically to study the the culture and traditions of food and how they related to health so this is a long time ago before people talking about the Mediterranean diet I was living it by being there in in Northern Italy and in in in traveling all around I went over to Greece I even went mountain climbing because that's something that was a a hobby of mine back then and I climbed up in the this area called Mount AOS which is like the Theocratic Republic of Eastern Orthodoxy to get into monasteries to study how monks or vegetarians live their lives and I volunteered as a chef in a monaster um and you know and like was stirring beans with this like canoe size spoon um in this cauldron in this Monastery that like cooked everything by fire um and so you know like yeah I I am a foodie and I I think that again this intimacy um is something that's very personal to me as it is to everybody but I love like exploration I I just think that you know um I would tell you I love food I respect food I I wouldn't say I love to eat so I'm not somebody that shovels food down my mouth I I like to taste I like to explore I like to understand and I and I think that that's a a something I like to share with people I really appreciate that and I can I can totally relate as well you mentioned as one of your five pillars uh the immune system and you know we've heard a lot about inflammation inflammation is a feature of the immune system uh it's not necessarily bad it's not necessarily good can you talk to my audience a little bit about what inflammation is and maybe the foods that can help dampen inflam in the body because we know that inflammation plays such an important role in the ideology of chronic disease absolutely so um first of all if we didn't have inflammation we probably would have died as kids because when we cut ourselves you know on a swing set or you know on building blocks or you know a scuffle in the schoolyard or whatever it is um you know that cut that you get we fall off your bicycle you skin your knee what's the first thing that happens you get a little bit of redness it's painful you get a little bit of redness a little bit of swelling that inflammation that's inflammation that's our body's natural first line of defense and inflammation uh is a is just one part of our immune system it's the front line and it's designed inherently to get rid of bacteria that might enter the body if we actually are injured so a little inflammation is really really important and what our body knows how to do is to ramp up the inflammation quickly which is why when you cut yourself and you get that swelling within seconds right definitely within minutes and then what happens over the course of a day or two days or three days your body tones that down turns the volume way down and then turns it off so inflammation is a defensive part of our immune system that our body turns on and then turns off if you can't turn it off you get chronic inflamation inflammation and that's the problem that we see in chronic diseases in diabetes we've got chronic inflammation and heart disease chronic inflammation cancer chronic inflammation and chronic inflammation triggers other diseases as well it's kind of like um here's the analogy um we know that when man humans made fire we suddenly had the power to be able to warm ourselves and cook our food okay um and we want to keep that fire in a little fire pit um and and that's where fire was useful to us and we know that you know after the evening you put the fire out then you go out and forage or whatever it is so turning it down at the very end now imagine if the Fire doesn't go out and worse imagine the fire pops out of the fire pit and catches the forest on fire now you got the Wildfire right and this is what's going on in our country right now we got these raging wildfires going everywhere destroying things that's what happens that's the inflammation we were really talking about but I I always try to point out to people you don't want to eliminate infl inflammation you want to kind of turn it way down so what are some ways to turn down inflammation using food again here's the science um it turns out that there's a lot of different food substances that can turn down inflammation green tea will turn down inflammation um vitamin C simple vitamin C which is found in so many foods can also turn down inflammation so um red bell peppers strawberries um guava uh Tomatoes oranges citrus of course are great sources of vitamin C I just gave you a handful of things you could sprinkle over the course of the day now how do we know that vitamin c does this again it's not theoretical like that's one of the things that I try to bring to the table is you know what happens in a lab is in a lab you know it's like Vegas you know um stays in the lab but what happens in people well that actually makes a difference and you find it in the lab and in people now you got my attention well so Studies have been done with people with inflammatory autoimmune diseases where they've got like runaway inflammation and there was a study in Japan looking at lupus so in the Miyagi prefecture in Japan there's like this lupus Center where you know it's like a lupus out of control and they found that people women mostly with lupus who had this chronic inflammation that if they that those women who ate more vitamin C containing foods like guava Tomatoes strawberries you know all those kinds of things bell peppers they had high levels of vitamin C and they had lower levels of inflamation as measured by CRP and they had less lupus flares that's human that's feasible and that can be delicious as well yeah so I have to ask um have have there been trials to look at supplemental vitamin C and have they seen the same results because that I believe that that study that you just referenced I mean it sounded to me like like an observational uh study right so have they been able to tease it out and look at and look at supplementary vitamin C so so here's not not yet to my knowledge and here's part of the problem once you get to a randomized double blind Placebo controlled clinical trial approved by an Institutional Review Board in a hospital and you want to get these PES with lupus the the research um is now changing but the old school way you're going to get people to run away out of control lupus at the end of their game okay uh and then they're going to be also to be on steroids and they're going to be on all these monoclonal antibodies and now you're not really studying kind of the real world anymore you're you're taking the train wrecks the worst of the worst and trying to see if a vitamin is going to make a dent I'm talking about people that you know are living their lives normally not in a hospital and are just trying to get their stuff under control right and and so that's where these observational studies um are to your point their important hypothesis generation but the hypothesis should be tested but the hypothesis is also easily tested by people as soon as they hear about it in their home that night when they after they hear about it um food has immediacy so what I would say is that we should all be eager to conduct our own clinical studies on ourselves if we think that there's a study um and good science uh that actually points a finger towards a Direction that we can actually get behind yeah one of the most I think uh typically when people think of inflammation and and supplements that are commonly uh talked about uh that think fish oil omega-3 fatty acids what are your thoughts on those as a potential anti-inflammatory um the the the fish oil has been studied as a supplement um uh and you know I think that the large body of evidence is that it does have good anti-inflamm fatory benefits it lowers CRP um it can improve arthritis symptoms of pain and swelling and lower medication uh needs and it also seems to have some improvement in Dementia in clinical trials like prospective clinical trials and they think it's by lowering inflammation as well so again um yet another kind of I would say brick to put on this wall that what we eat can make a difference but here's what I what I would tell you like some people um love to take supplements I know people who you know they that's their thing they want to take a bunch of pills in the morning and and they feel good about them and I'm I'm okay with that but if you can eat if you can get the if you can get the same substance from a whole food and get your protein um and get diversity because our bodies are designed for diversity we're not we're not onetick ponies you know so um uh if you can get omega-3 fatty acids from eating salmon anchovy hake sardines Manila clams you know I think that's great because you're you're getting you're testing your body you're you're you're you're stretching your body's repertoire of responding to the things we're putting into it in ways that activate your health of enses and that that that's my own personal way of actually trying to get Omega-3s yeah I I would definitely have to agree with you because you're also getting all these other as you mentioned protein but even on top of that there's all these additional nutrients um that are strengthening strengthening the the entirety of the system you know take salmon for example loaded by the way here here's a cool piece of research a lot of people don't know um cbass which also contains omega-3 fatty acids have been found by researchers in Guang Joo to actually contain a they think it's a peptide but it actually it's in the meat itself and and you know only recently discovered that actually speeds up wound healing and so like that that's a really cool idea and and and that's to me you know scientists get excited by the unknown a lot of people think that scientists spend all their time talking about all the stuff they know the brainiacs actually when you get a group of scientists together like when I have when I get together for dinner with my my Science Buddies you know it's not that we geek out talking about all the stuff that we know like Engineers you know like we scientists biology scientists actually SP spent a lot of time talking about what we don't know yeah you did you know did you know what we don't know like how do we how would we answer this question and that's what I would say is um so exciting about food and health we are really at the beginning of a new era of really being able to truly understand not only what's in our food but how our body responds to what we put inside it and metabolism is a whole other dimension of this that is coming down the pike as well yeah and we know it's so important especially over the past year metabolism and metabolic Health has really come into the spotlight as being something that we all need to be ought to be conscious of think about this aquarium that's got fish that you want to keep these are your pets and it's also got um overgrowth of algae you know like that completely overgrows the tank and that algae is going to kill the fish right you get enough Gunk growing in that tank you're going to kill the fish so what can you actually do to clean up that tank you want to get rid of the algae but you don't want to kill the fish that's really probably the best analogy of this micro environment situation in any organ that we have in our body where you want to get rid of the cancer cells but you don't want to actually um kill the healthy cells Well turns out that cancers are exquisitly sensitive to um uh blood vessels as I as I told you and if you cut off the blood supply to um cancer uh it's it's kind of like uh lowering the bubbling uh the the air system into the aquarium so you got enough just for the fish but not enough for the for the algae to grow uh and the body knows how to make that diff diff difference so for example blood vessels that are feeding normal cells are really well constructed did like a like a think about a house that the architect really made really strong it's got good pilings it's got good infrastructure the frame is really solid the windows are really nailed down tightly and a cancer when it grows blood vessels to it doesn't do it really well so that's like a crappy contractor that that cut all the corners and so basically the house the the blood vessel system feeding the cancer is like a like a crappy house when the hurricane comes okay guarantee you that the vessels that are feeding the cancer are going to come flying apart but the ones that are feeding the healthy cells the well constructed ones are going to stick around they're going to outlast the storm and that's basically what we can actually do with anti-angiogenic drugs now foods can do the same thing there are many things in Foods these bioactives we talked about that you know Mother Nature laced into plants you know kind of like Mother Nature's Pharmacy with an f um uh actually can actually um help to mow the lawn and get that tame those blood vessels so that if they're growing towards the cancer you can kind of prune them back trim them back to normal and it prevents the cancer from growing new ones which is really really important for cancer prevention that's just having enough of that mure to prevent blood vessels from overgrowing um is really can be really important so what are some of the things green tea um uh you know which everybody knows as antioxidants which can actually lower your blood uh sugars um help to lower your cholesterol lower your um stress levels catac colomine actually is super packed with these cakin egcg one the main polyphenol that is anti-angiogenic so way back when when I got in this field we had a test system where we were testing Cancer drugs that could starve a cancer by cutting off its blood supply and on and one of the things that I did is I actually dropped some green tea in there and you it was shocking how effective the green tea polyphenols were in stopping those blood vessels that were feeding the cancer uh and in fact if I didn't tell the technician doing the lab work that it was actually a natural compound um and I told them it came from a drug company they would have like they would have been super excited about it and started jumping up and down and so again you know Mother Nature is really really um good so polyphenols and te uh egcg is one of them um Resveratrol and red wine also another one um that's actually really really powerful uh in terms of uh being anti-androgenic genestin the phytoestrogen and soy actually can also cut off the blood supply feeding breast cancer so it's just the opposite of the urban legend out there that soy is not good for you I recently saw an article it was a cover of a magazine that said you know soy anti- nutrients or something like that and I you know like I I my mind was blown that somebody could actually say that because most of the nutrients including the proteins but also the phytoestrogen and soy again you know if you're a scientist you take a look at this um and the phytoestrogens look nothing like human estrogens they're not dangerous they actually block human estrogens and they actually are also anti-angiogenic and they cut off the blood supply to breast cancers and this has been shown in human patients breast cancer patients uh as well um tomatoes have lopine so many of the you know the same foods that we know are good healthy plant-based sources of nutrition we're now rediscovering that many of the bioactives in them are also powerful cancer blood vessel cutting cutting off systems that cut off the that starve starve a tumor you know the really the point that I want to drive home here is that you had this quote in your original Ted Talk and he said as a doctor I know that once a disease has progressed to an advanced stage achieving a cure can be difficult if not impossible and the reason that you were sharing this in the context of your presentation and your Ted Talk was you were helping people understand that this is one of the main d of why you got interested in the topic of food this is something that we do two three times a day and if that food could have just as similar of an impact in some cases even more so then it's not what's better food or medicine they're both great but food is something that we all have control over and because of Education gaps in healthcare practitioners again well meaning they may not have the education in food this is something where we're empowered as consumers to start making a difference in a dent because as most of us know you know there's a there's this area that's in between you know you don't have cancer and you're diagnosed with cancer right it's not like one day you just show up at the doctor's office and then cancer came out of nowhere it's growing always sort of in the background at least the conditions are until one day something changes and then it has that explosive growth so if we can make a difference now then we're more empowered to actually change our health and hopefully minimize or potentially even avoid some of these chronic diseases later down the path absolutely I mean you know my my uh how I got into nutrition molecular nutrition was was that um you know taking care of patients who were terribly sick what is incredibly rewarding and giving them uh an answer to why they're not feeling well and helping them trying to get solutions for that is is such an important privilege uh to be trained and to be able to actually do but you know um uh when I started to see I'll tell you an interesting story so I I was a doc at a Veterans Hospital love taking care of veterans most of my patients were their 50s and 60s and 70s and older uh and many of them were um overweight uh if not morbidly obese they had about heart disease lung disease diabetes cancer um uh the bone diseases I mean you name it they there there were all the problems that you would see in an older person but the thing that really struck me as I was writing prescriptions and sending people to Specialists was the jux deposition of these individuals who in their second half of their lives you know 60s and 70s terribly out of shape riddled with disease you know and I was trying to help them but I also looked at these people and realize that you know if I put on my spectacles of the time machine the same individual going back when they were 20 years old was cut fit buff as a soldier in fact they couldn't even serve in the military unless they were in perfect shape right and so what happened to these people over the course of their decades over the course of their lives is they've lost control of their health and that's what made me realize treating the horse out of the barn is something worthy of doing but why do we want to wait for that why don't we actually prevent disease in the first place and when you T when I was thinking about prevention you know you really can't think about drugs I mean because drugs are expensive they got side effects really difficult to develop a preventative drug and who would want that anyway um but food naturally lends itself to prevention because that is indeed the the intervention that we take multiple times a day and in fact our food is the intervention is the health care that we do for ourselves between visits to the doctor's office I mean we've come to regard Healthcare as what we do when we you know make an appointment and step into the door and get weighed by the nurse before we sit on that you know that cold um paper filled table exam table but in fact most of the health care we're doing is uh between the time we go see the doctor it's so true and if we're fully gonna understand the impact that food can have to going back to that analogy you had why is it that this cut healthy ripped soldier at the age of 20 and then you contrast them fast forward a few years you know 40 years they're 60 years old and their systems are starting to fail their angiogenesis in some cases is out of control in some cases it's under producing where it needs to be what happened in the interim and and in your book you really highlight that in addition to angiogenesis there's really there's with angiogenesis there's five areas there's five sort of key areas that we have to look at these sort of systems in the body to understand what happens when we go from being healthy to being in a place of disease let's walk through them starting off with the you know you can pick which one you want to start off with next and and we'll give a little bit of an overview just like we did with angiogenesis yeah sure Drew I mean this is such a great question I'll tell you how I got into it because I think that's the best way to to to to articulate this for your viers um you know as a doctor I was I was always trained to W wonder why somebody got sick what did they do what was going on in their bodies that led to an illness and in fact most patients always ask me you know like well so what happened how did I get this you know how did I contract this condition um and that's how I was trained to think for for decades but reality is um and and and as a researcher that's what I was looking at is what is the underlying cause of illness but I think I I discovered there was a much more interesting question and that more interesting question iswh don't we get sick more often you think about it like kids are usually pretty healthy and actually when you're in the prime of your life you're generally pretty healthy yeah you might get a flu or might get a cold every now and then it's only when you get older that you start getting sick and the more interesting question is like why don't kids get cancer more often than they do why don't healthy adults get more heart disease why don't they get diabetes you know like more often than they do I mean some people do at a younger age and so that's really by turning that question about why did I get sick into why aren't I getting sick more often that led me down this direct path to saying what is a body doing to prevent illness and if and and what is health itself if you know the the the question the way that I would use to answer the question what is health is like yeah well you know you're healthy if you're not sick and I think that's how most people would answer it turns out health is not just the absence of disease health is the result of our body working firing on all cylinders to keep us that way into and ward off illness and um and what keeps us healthy what Wards off illness what is firing in all cylinders are Health defense systems now I found five Health defense systems and I wrote about five in my book Eat Deb disease because I've worked in the drug development field in each of these areas Andrew Jenis is one of them let's talk about all five of them first blood vessels i' I've done drug development in helping to grow blood vessels and stop blood vessels second our stem cells I'll come back to that I've done work Decades of work in developing regenerative medicine to try to regenerate organs uh that's amazing what you can actually do in the biotech world with that third is the microbiome I've done research on the microbiome with colleagues at am it and elsewhere fourth is um genes our DNA and most people think of our DNA as sort of the genetic code um I've done gene therapy so I I've actually helped to develop Gene therapies um and fifth is our immune system and our immune system which is hardwired this is more important than ever before in immunotherapy for cancer for example is one of the most powerful breakthroughs in in medical in the medical world today so I've got the street cred of doing drug development in each of these areas but rather than thinking about using drugs to activate these systems if we turn the sock in side out and take a look at okay so how do these systems actually defend our health bar circulation prevents um uh to feeds our prevents Disease by feeding our healthy cells and preventing bad diseases from growing like cancer our stem cells by the way um you may not know this but all of us have about 75 million stem cells that are in our bodies at any given time we're actually made it of stem cells because when when we were in our mom's wombs the only reason our bodies were able to even form a human figure like you know the little Playdoh that kind forms humans in the womb is is because of stem cells and we retain some of those after we're born and we lock them up in our bone marrow and in our skin and elsewhere and our bodies regenerate continuously that's one of our health defense systems because you know you know as we age we need to repair ourselves from the inside out like we know um our hair regrows for most people we know that um even our G our mucous membranes are are are this sort of skin in our mouth where we grow anybody who's ever you know um had a really hot uh something hot piece of food and you burn your mouth and like man like it it totally screws you up next day you're back to normal because your your skin in your mouth your mucous membrane regenerated okay it's like eating a Dorito and you scrape the top of your mouth next stay you'll be fine because of regeneration um but what's amazing is that our organs regenerated from the inside out if I took your liver and we cut off 2third of your liver and left one third left it would regenerate the rest of the 2/3 just like a starfood to regenerate an arm um your lung if I cut off the tip of your lung um it would grow right back and what we're starting to realize is that the The Playbook of human biology is being WR is being Rewritten because when you and I were kids I'm sure our grade SK School teachers taught us the same thing starfish and salamander regenerate but people don't wrong people regenerate and so now we can actually try to coax this regeneration to go faster it's one of our defense systems but um and while biotech people are trying to figure out ways to make us regenerate foods can also cause us to prompt regeneration as well which is really cool um foods like chocolate foods like dark cacao like dark chocolate cacao polyphenols can actually stimulate regeneration um there's all kinds of other uh uh uh biotech kind of things that can actually do this but Mother Nature has laced um things that can be regenerative like ursolic acid and fruit peel can coax our stem cells to come out of our bone marrows to to stimulate regeneration as well I mean imagine a future in which we understood how to match the uh the substance in a food that naturally occurs with something that we need like brain regeneration for dementia for example that would really be a GameChanger and so that's where the future of understanding our B's Hardware self- defenses for regeneration goes microbiome you know we've got like 39 uh trillion bacteria in our body most of them in our colon and we know that when our gut bacteria is healthy it controls our hormones it controls our cholesterol metabolism it controls how our how our body uses blood sugars when we screw up our um gut bacteria it screws up everything like literally we've got an ecosystem inside our body that if we don't take care of that ecosystem um it destroy it wrecks the rest of our body and and something that's stunning to know for example is that um uh uh is how vulnerable the system is artificial sweeteners like you find in a diet soda can in 24 hours overnight start to destroy your gut microbiome the healthy gut bacteria start to change they don't like that artificial sweetener because they're trying we don't absorb those those calories right those are the those are the non-caloric sweeteners so we get the taste in the front end in the back end we don't absorb it so we don't get the calories but guess what our bacteria are eating those things too and they don't like it we're poisoning the field when those bacteria um don't like it and they start dying it affects our metabolism it affects um even our hormone our brain hormone so we want to keep our our our gut defense system which is tied to our immune system by the way really really healthy um our DNA is another defense system um people don't realize this but we make 10,000 mistakes in our DNA every single day that causes mutations which then can cause cancer so fortunately our DNA system defends us by fixing itself and our immune system of course is um like an our ultimate Shield um to prevent us from bad guys coming in from the outside whether it's covid or whether it's the flu or whether it's you know some other uh uh germ but also our immune system protects us from bad guys on the inside of our body and that's those cancers that we started talking about our immune system conducts surveillance to take out those bad guys inside our skin as well I know you're a big fan of olive oil I want to talk about olive oil and why it's so beneficial but before we get olive oil in the spirit of the kind of foods that we should think about limiting when we are in our Supermarket or our grocery store and we're looking around to purchase oils to cook food in to sprinkle on food to pour on our salads what kind of oils should we try and avoid and then what sort of oil should we try and buy in stats you know so this like the debate about our artificial sweeteners um is a loaded topic and so I I want to just start you know this component of our conversation by saying the jury is still very much deliberating what oils are harmful to you and and are most harmful to you U but I think that it's less controversial what uh oils are better for you and good for you I want to you know for your listeners I want to kind of give people some real practical things just kind into the science of petroleum products which is what o oils are let's talk about this rule number one regardless of what oil you actually have what I would say is don't have too much of it because oils are fats and fats can be healthier but there really isn't such a thing as a healthy fat that you should like drink lots of it every single day okay so the point is that there are healthier oils but you should we should all limit the amount of oil that we actually intake into our body all right number one number two is that and this is actually broadly speaking is don't reuse your oil okay most oils that are reused when we heat them to cook whether we're actually you know uh I mean again deep frying is generally something that's not very healthy the process of deep frying actually changes the chemical the natural chemicals that make up oil in the oil itself and then paint it onto the food stick it onto the food so we're eating some of the change chemicals when we actually eat deep Pride food now look I mean I I've had I've had some awesome fish and chips um when I visited England before um and and again and again as we talked about you know every now and then if you're you spend most of your time Shoring up your health defenses raising your own bar you know having a rare treat it's totally fine but when you fry things in hot oil you're also changing the chemical structure of things that entire Browning golden Browning crisping of food actually Chang changes the chemical structure of the food itself and in ways that are potentially carcinogenic and so just need to be careful about that the third so so I think you know like reusing oil here's the thing that's kind of like a little risky you go to a restaurant to eat you have no idea if they're reusing their oil over and over and over again you know um I mean think think about in uh Asian restaurants whether it's an Indian restaurant or a Chinese wrest they've got these gigantic Vats where they're frying tasty little bits up um but they may be reusing that oil for days so um reused oil not good for you for sure and and the stuff that's fried in oil can also change in time so let's start now talking about just like the the properties of oils themselves this is where I think rather than kind of walking into the quick sand of trying to say is palm oil better than corn oil is coconut oil dangerous for you you know like we can weade into that jungle with you know but I think you need a machete to cut your way out of it and so the best way to think about it help to give clarity is you know are there any healthier oils to use and how to use them and this is where I think olive oil really stands out number one it's part of a healthy pattern of eating that's been revered for thousands of years and that's in the Mediterranean traditional Mediterranean diet and the olives are seasonal they're pressed the extra virgin olive oil contains not just fat poly monounsaturated fatty acids which are better for your body and less damaging for for your cardiovascular health but there's a lot of polyphenols that come from the olive itself now a lot of people don't understand this but when you look at olive oil the reason we say extra virgin olive oil Evo you know that's what the that's what supermarkets and what restaurants are proud to use now is because it's not just fat it contains the polyphenols from the oil so if you were to actually by the way this is a good experiment to do for for your listeners buy a little container of Olives from your grocery store pitted make it easy for yourself and literally you know take it home and and take a a heavy glass or take a a board like a like a heavy cutting board and press those olives yourself and you'll actually see if you press hard enough you'll see some oil come out of it now in a in an olive oil factory I mean that that's that's so you can actually appreciate where your food comes from where your olive oil comes from now when you actually press it you'll see that you've crushed the olives and some of the bits from the olives are actually in the olive oil the reent olive oil tastes so good it's got that you know kind of um peppery vegetable kind of quality to it um it's got a Umami flavor it's not because the fat is flavorful it's because the bits of Olives that were crushed in there are actually in there flavoring it now those bits and the stuff that comes from the meat of the olives contain the polyphenols one of which is hydroxy tyrosol hydroxy tyrosol sounds like a very complicated chemical name you don't your listeners don't need to memorize it by any means but you should know that that comes from the olive now olive oil will have some of it only about 20% of the of it but if you actually press that Olive 80% goes into the olive water and and it's stuck in the pulp and so one of the things that I always say is that you know if you really love olive oil and you want to get the most out of it um just eat the whole Olive you know and you can actually cut up an olive and you'll get a little bit of fat you'll get all that flavor and you'll get a lot more of the polyphenol now if you're going to cook with ol olive oil I I I always say go for extra virgin because of that reason I would say don't deep fry but but you can spr you can put put some on uh to food you can actually sauté with it not too much all the studies show that about three tablespoons of olive oil that's sort of like what you probably that's around the max of what you'd want a day so nobody's drinking olive oil and then the other thing that is if you want to choose which olive oil because I get overwhelmed when I walk into a store and I see all these like a whole wall full of olive oils right everybody's marketing here's what I do again I pick up the Olive and oil and I look at the ingredients what do I look for I look for mono verial olive oil monovarietal means it's made with just one kind of Olive and I look for the one kind of olive that that that oil is made from from three different varieties of Olive in Spain Spanish olive oil I look for p p i c l picu olives among the highest in in polyphenols in the oil so the olive oil will be loaded second um Greek olive oil um the coroni olive which is from the pelonis it both both of pyan Cori are very common olives so that's a good news it's not very expensive highest amount of poly one of the top three polyphenols and the third for Italian olive oil I look for um uh oil that's been pressed from a monover varietal called morolo and that comes from Umbria and there that's less common harder to find a little pricier but I just gave you Three Olives uh pel Cori morolo uh that are not most of them are not good eating olives but they're great for olive oil they're packed with polyphenols if you get olive oil that is monovarietal pressed only from each of those you can be guaranteed that you're getting sort of the top the sort of the coo too of the polyphenols in the olive oil yeah I love that I I actually in in my kitchen as we speak now it's the PQ Olive it's a Well I would have called it a single origin but that's because I'm probably used to picking coffee but as you were describing that there was such a wonderful energy in your voice and your body language it reminded me of like a wine connoisseur talking about the different varieties of wines or a or a coffee coniss talking about that you know I get the single origin bean from this particular Farm but I guess it's not that different is it it's about going back to where does this come from how was it processed what is actually in my hand right now that I'm about to buy yeah and and you know there it's great pride that we as humans have always had and it's still within us to know something about the food that is around us I mean you know uh if you talk to a farmer they are proud of what they have if you talk to a villager they're really proud of what their Community what grows around their community and again I think that you know something that maybe that we're fighting against because I I want to draw back the jargon that you raised at the beginning that I think is helpful to think about what are we what are we really fighting against you know I think we're we're fighting against our distraction from ourselves getting to know who we are and getting what to know slowing down so we can actually understand our own pace we're getting distracted by the uh by the by the pace of what we're expected to do and so we've got no time for ourselves right I mean every every young working parent certainly feels that way you know like man I'm so busy I don't have time for myself and yet when it comes to Food and Health we all need to have that time for ourselves and I think we should take great pride in saying what it is that we actually love yeah a lot of people talk about the health properties of vegetables of course you promote all kinds of vegetables which have different impacts on the body but some of the time we're told to sprinkle or pour some olive oil onto the vegetables because it helps us absorb nutrients from them what's your perspective on that in view of what you've just said about oil and you know perhaps not over consuming it even though it can be healthy yeah well there's two let's unpack that because there's two things that you were describing one is that in Plants let's take a tomato as a great example uh there are natural substances natural chemicals like lopine lopine is a carotenoid it helps to make the tomato red um it has lots and lots of healthful properties it's a powerful antioxidant I've studied lycopene in a laboratory and it actually can help starve cancers by cutting off the blood supply um it can slow the shortening of tiir to slow cellular aging and it and it can protect our DNA from even sunlight and UltraViolet exposure lots of good things about it now lopine actually is a uh uh naturally occurs in a tomato on a vine in a chemical form that our body doesn't absorb that well so if you pick a tomato off the vine and you cut it up and you throw it into a salad it might taste great just got some vitamin C in it it's a great source of hydration and great flavors okay especially if it's like a homegrown heirloom type of tomato but you're not going to get the like you're not going to get as much lycopene you're probably only going to get maybe 20% of the lopine that's in there but you want it like for me I want to get as much much of the good stuff as I can so here's what researchers found if you wanted to convert that chemical structure of lopine into a form that you can absorb better your body can avidly absorb what you want to do is you want to heat the Tomato like in a pan and with the heat will change the chemical structure from a form your body doesn't absorb that well into a form that your body avidly absorbs loves to absorb it now you go from 20% absorption to 80% absorption you flip the you FP it around completely upended that equation completely now you're really absorbing it now here's one additional thing though how would you heat a tomato in a pan you put heat it in water or nothing no not really you put a little bit of olive oil in it and why is that and and it's because lycopene is a substance that we call fat soluble it's a lipid it loves to dissolve into fats so a little bit of olive oil in tomatoes on a pan sauteed so it's soft change of chemical structure flavors are really great now and you have that now when you uh eat that tomato sauce sauteed in olive oil the oil the olive oil with the lopine is carried into your body even more efficiently than if it were cooked in water and so again that's an ex that's just one example of thousands of how oils with fat soluble Foods by the way if you didn't want to look at olive oil here's another common snack in the United States anyway is kind of ter a pagebook from Latin American Cuisine you have these tortilla chips and then you wind up actually having salsa and guacamole the Salsa Salsa is often sort of stewed down Tomatoes cooked down Tomatoes served room temperature or chilled and then the guacamole is just avocado that's been smashed up now avocado has a lot of healthy fats in it it's it's it's a fat soluble veggie it's actually quite nutritious remarkably uh people eating avocado actually shrink their waistline because even though eating fat it actually makes you it burns down harmful fat it's a whole other story that be had but if you have guacamole avocado with tomatoes you get more lopine and so that happens to be kind of a popular snack uh in the United States yeah I love that so the right combination of foods can actually help absorb the nutrients I think black pepper also can do that right with s and nutrients well right so black pepper so this is an interesting thing we most of us have heard that turmeric which is a kind of a a root um when you cut it open it's this bright beautiful bright orange a lovely color and and turmeric is also a dried spice used in Southeast Asian Cuisine uh including Indian Cuisine is where I first became acquainted with it it um not only makes food beautiful it actually makes food delicious it's got a quite a lovely taste to it it's a it's a spice inside turmeric is kirkin circumin is one of those natural chemicals kind of like lycopene it's one of those mother nature's Treasure Chest Mother Nature's Pharmacy with an F not a ph and the the the the the circumin has a lot of properties anti-inflammatory it's antioxidant it cuts off the blood supply feeding cancers um it uh actually is helpful for your stem cells as well it's it really activates almost all of your body's Health defenses and it's good for your gut microbiome so why not just you know enjoy turmeric as a spice by itself because it's so potent that our body actually doesn't absorb everything that it could in fact our body kind of it kind of gets a lot of it gets flushed out you know uh the tail end and so what we want to do to improve our body's extraction of the good um the good stuff the the termic it turns out that if you have fresh cracked black pepper all right there's a substance in fresh cracked black pepper called pepperine pierine is one of Mother Nature's um again you know these remarkable chemicals that actually in influences the body and piperine helps the body hang on to the curcumin so if you have fresh cracked black pepper with your turmeric uh you you're actually creating a onew punch that allows you to absorb more of the curcumin sleep in cooler temperatures helps to activate your brown fat pet when you're sleeping amazing yeah I have a I have a I sleep with a um one of these mattress pads that cools my mattress it not only increases improves my sleep quality but that's cool to know that it that it's probably encouraging the proliferation of this of this helpful fat and it also helps you sleep better builds your immunity there's all kinds of new things that we're beginning to realize at cooler temperatures when we're sleeping which probably mimics sort of the natural state of the outdoors at night the temperatures drop right I mean it's only in a house with a thermostat we crank up to have sort of warmer temperatures at night yeah do you have a is there like a specific temperature that we should aim for when setting our thermostats at night you know people talk about this kind of a range it's probably between 65 67 degrees it's sort of under 70 it's not freezing like you you don't want to be shivering at night right all right but it's sort of in the high 60s H okay so sleep make sure that you're sleeping in a cool environment but what are what are these Foods okay the thing that I found so amazing that I write about my book is uh that foods will actually uh click on your brown fat to burn down harmful white fat it'll elevate your metabolism it'll also help you lose weight and it'll shrink your waistline by killing off off by shrinking visceral fat that harmful gut fat all right so before I talk about the exact Foods I want to kind of just may give a little more depth to understanding how the healthy parts of fat that we've just been talking about because we just spent you know a little time talking about healthy aspects of fat don't fearure fat you don't want to get rid of it you don't want to cut it out burn it out like you you want it you want your fat yeah and by the way you don't want to poison your fat either what do you mean by that well I mean you know like people are developing as as you know like in the news are talking about it all the time ways to block obesity and you know and can we actually Target fat and get rid of fat that way we have to be really careful you don't want to interfere with these normal healthy functions of fat the fat that the baby has the fat that we normally have to operate our organs so let me explain basically a little bit about metabolism fat and then food and then we can talk about which foods actually will really be helpful for ramping up your benefit right so um think of your car H think of your body as a car right so what is metabolism metabolism in your body is basically like the way that your car transfers fuel to run its engine you want to get from point A to point B you're going to drive your car the engine needs uh fuel needs gasoline and so you're driving your car and you're paying attention to the fuel gauge when the fuel gauge looks like it's heading to empty what do you do you pull over your car go to a filling station take out the gas pump put the nozzle into the gas tank fill it up all right and then when the gas tank tank is full the the nozzle goes click no more gas put it back and you drive off with a full tank right now in our body our body requires it's basically an engine our metabolism gives our engine our body engine all the fuel it needs the fuel that we get in our body isn't gasoline the fuel that we have comes from our food now people have used the term calories to describe that energy unit but I don't want people to get focused on the calories because people tend to get too fixated on how many calories counting calories calories in calories out I want to explain something to you in a maybe easier to understand way food that we eat is our fuel when we eat uh our food our body senses fuels loading up just like we're at a filling station so what happens is that our insulin levels go up because we are having food in our body insulin is that wonderful hormone produced by our pancreas that draws in the energy from the food that we just ate into our cells so just a power up our our cells we need to have enough energy anything extra gets put away into the fuel tanks which you remember in the womb our fuel tanks are fat cells little tiny fat cells that ring around the blood vessels they actually get filled up um you can fill up you can stretch a fat cell hundreds of times wow okay um so but but if you put in a little extra fuel it's just there you're loading up your fuel tanks when you're not eating your insulin levels go down and then your body says okay now we can switch over to fuel burning mode it's kind of like when you pull over to fill up your car fill up your gas tank you turn off your engine you're not burning any fuel right so when you're done fueling up you can turn on the engine and go drive and start burning the fuel again right body's done the same way all right so now uh when we're done eating insulin levels go down our body our metabolism switches into fuel burning mode makes perfect sense where does it get the fuel it gets the fuel from blood anything in the cells and then when it needs to it Taps into the fat m all right now then you're driving off and then what happens is when you actually your fuel cell when your fuel runs low our brain senses that gas tank says is low what do we do we don't pull over to a gas station we pull over to the dinner table to the restaurant to the refrigerator to The Pantry all right so you can kind of see this is a very very common sense way of understanding our metabolism which which can be very complex if you talk to a scientist I'm trying to boil it down to something easy now here is something interesting remember I told you when you're not eating you're able to burn energy and that energy is stored in fat cells which can get bigger and bigger and bigger when uh you actually eat more and more food fuel all right so when you're not eating like sleeping we talked about sleep you're actually burning fuel so sleeping is a fuel burning State our metabolism is naturally switching into fuel burning because insulin is low we're not eating and we're actually burning and basically what happens when we get up in the morning okay it's burning burning burning all night in morning we get up we bre we eat breakfast we break our fast all right so when we're sleeping we're fasting and this is basically where the idea of intermittent fasting um comes from it's just describing what we normally do yeah and it's not just a trend or a fad or you know something some crazy new kick that people should get on it's actually very very natural to our body the longer we give our body time to burn without food to be able to tap in to do fat burning energy sucking shrink those fat cells the more weight we're going to lose the more fat we're going to burn the more fit we're actually going to be and the more our metabolism is actually going to rise so basically I want to kind of give you an example of how this might work in real life let's say you go to bed at 11 o' and you sleep for eight hours so you get up at 7 okay that's pretty typical for many people let's say that you eat dinner so you have eight hours during that sleeping time let's say that you eat dinner at seven o'clock and you finish at8 put your dishes away at 8 o'clock now no midnight snack no dessert later on no noshing munching on chips or whatever sweets but at 8 you're done and then you actually just go up about your way and you go to sleep at 11 you've gained three extra hours to your eight hours now you've got 11 hours of fat burning all right that's that's to your advantage yeah your body your metabolism is burning now let's say you get up at 7:00 all right 8 hours of sleep and now you rather than actually get up and do what your mommy told you to do like we're all conditioned this way get up eat breakfast hurry up catch the school bus and get off to school all right let's say you get up and you take a shower you get dressed you putter around a little bit check your emails or do whatever to scroll through the news wait an hour okay before you eat breakfast before you break your fast now you've gained an extra hour to have your body burn fat so now that's 1 hour in the morning 8 hours in the evening 3 hours the night before okay that's 12 hours so you've taken half the day to burn to up your metabolism by burning body fat that's an easy way to think about intermittent fasting in a completely different way it's not 16 and8 16 fasting eight e eight hours eating that's pretty intense if you want to squeeze all your eating in eight hours yeah all right you might not be enjoying your food and might be a to socialize the same way way and there is something to 16 and8 that's been studied in animals and a lab it's also been studied in humans but I wanted to sh share with you that 12 and 12 12 hours of fasting not eating just like I just described compared to 12 hours of eating also helps you burn fat and also helps you lose weight it works as well so you don't have to be an extremist to you know put the pedal to the metal to really really go hard at fasting just ordinary kind of patterns will do that now this is a setup for the food by by the way so I just told you that the uh that the uh way you eat the timing of the way that how you eat actually can be uh uh very very useful for fat burning I also told you by the way this overload of gasoline which I want to talk about in a second um is important so how much you eat also makes a difference normally yeah before we get to the what all right so um imagine you're filling your car with with gas again you're back at The Filling Station with your car you get your noil when gas tank fills up imagine if you didn't have the click on the nozzle right and the gas keeps on flowing out what's going to happen the gas goes up it f it runs out of the tank down the side of the car around the wheels pulls around your feet now you are standing fire hazard is hazardous flammable dangerous mess because you've overloaded your fuel yeah let's go over to the body you're eating eating eating now our body doesn't have a clicker on the nozzle when we sit down to eat there's no automatic cutof off switch so it's easy to overeat all right the more you eat the more you eat the more you eat now what's happening is that your insulin's up it's using the fuel everything extra gets stuffed in the fat now those fat cells remember I told you can actually expand massively if you really overeat you're going to stuff more fuel into the fat cells there's a limit to how big they can get all right so but you still have more extra fuel extra food it's going to make more fat cells wow okay those get stuffed okay then they go up still not enough storage make more fat cells Now you kind of see how overeating creates more and more and more and more fat yeah that's the difference between fat cell hypertrophy and hyperplasia correct that's right so hypertrophy is actually the small fat cell getting stuffed and getting bigger and bigger bigger um uh hyperplasia is actually when actually more of it actually starts to to grow and by the way those ideas of hyperplasia hypertrophy is like what happens in the muscle too gets bigger yeah hyperplasia is actually a kind of a pre- tumorous state it's like we use hyperplasia to describe pre-cancers wow cells are growing that should they be growing they get bigger and bigger and bigger and let me just tell you when fat cells get um are just being stuffed with fuel because you've overeaten you actually need more more fat cells they make your body makes more and more and more and they get all get bigger and bigger when fat starts to get into an expanding Mass fat as an organ just like any other organ needs a blood supply so when it outgrows its blood supply it desperately seeks to grow new blood vessels to it this is an area I study called angiogenesis fat needs to be fed it needs oxygen it needs nutrients but if fat is so continuously overloaded the center of the mass will start to die doesn't have enough oxygen that's called hypoxia hypoxia causes inflammation and when you have inflamed fat remember just standing in that pool of flammable Hazard okay now you actually got the the hazard is actually inside your body it's not around your feet wow all right that growing fat has this flammable inflammation Hazard and that inflammation in that fat basically wrecks destroys the normal function of the hormones in your body it wrecks um your Fat's ability to produce leptin now you don't know if you're hungry or not hungry maybe you're too hungry maybe you're not hungry it can't tell and it destroys a dip intin so even though you're eating there's plenty of energy you know what maybe you're not absorbing that energy very well now your blood sugar start to rise and then resistant it doesn't even know what to do anymore when do you put on the brakes and you can kind of see how overeating by itself okay and we're going to get to the quality of the fuel in a second but overeating in itself can easily uh your body just tries to stuff away the fuel but can easily tip things over the edge and that that that Tipping Point actually is where good fat gets deranged and turns into bad fat wow what a story and is this the point at which the the fatty the free fatty acids begin spilling over and getting stored in quote unquote nonprofessional storage sites in the body like organs where if you're not supposed to accumulate fat like like your liver yeah right so you've heard about non-alcoholic fatty liver disease very common to very common and it has it's it's actually tracks along with the Obesity epidemic pandemic that's going on around the world and basically what happens is that you make fat you make fat make more fat it expands expands expands now remember I told you your body's stuffing that fuel using the fuel tanks all right but at some point you've got so much fuel all your tanks are full and now the fuel is leaking out of the tank and when it leaks out of the tank it's got to go somewhere and some C certain organs start to absorb more of it like your liver so when your liver starts to collect fat you are starting to be in trouble because your liver is a filtration system the the the cleanser of your body detoxifier of your body now you start to plug that organ up you can't detoxify your blood very easily so you can kind of see by the way it's starting to make sense now right like how the simple behavior of overeating or not being mindful of the timing in which you're eating so you're not giving your body enough chance to burn down that extra fuel can have unintended and very deadly consequences yeah right and that's where the the science of of the metabolism actually comes into play so before we get to the what's kind of food what kind of fuel should we be eating let's say very simply put the more time you can give your body to burn down extra fuel the better your health is going to be meaning if you finish dinner don't eat anything afterwards as much as long as you can like I mean just don't eat after dinner put the dishes away and don't eat no more food yeah all right then you get then you then you go to bedtime then take advantage the whole evening and then don't eat breakfast right away in fact if you occasionally skip a breakfast that's even better because now you're giving your body extra um uh fat burning energy burning time all right so rather than kind of like become like really rigid about intermittent fasting I think if you have this self-awareness that your body is natural doing this this is actually a pretty easy way uh to actually start to leverage your body on your own behalf yeah I mean at the very least at the end of the day you're skimming off a ton of calories that generally are not the best for you right like like the the foods that people tend to eat when when curling up in front of the TV to binge watch their favorite show those tend to be not the most nutritious calories anyway right that's right that's right and actually so that then get to the the quality of the food you're eating right so think about it let's go back to the car because I think it's something that everyone can understand uh you know that if you buy a brand new car um they always tell you to put the highest quality of gas you can in your tank look if you in the beginning if you actually put crappy gas in your tank your engine is going to be running just fine it can take it a while but every day you actually put poor quality fuel in your car your engine is going to suck guarantee you over the long run it's not going to run as well as as somebody who takes care of their car by putting a higher quality of gas so for food it's the same thing our body remember our metabolism is really just kind of like an engine running the engine so the food that we eat which is our fuel really is like the quality of our fuel you put good quality fuel into your body your engine's going to run longer okay that's a longer healthier more vibrant living okay you put four quality food in your body look once in a while you're going to eat something that's not so good for you no problem if you're generally healthy you'll rebound we're highly resilient but what we're talking about are the people that Snack drink junk you know uh harmful foods uh and don't and pay very little attention to Quality Food mother nature in creating Foods um have laced these foods with natural chemicals right um these are called bioactives and they're called bioactives because they're biologically active and in a plant let look at a strawberry for example okay the tartness of strawberries you know there strawberries are sweet and tart the tartness comes from an acid unsurprisingly called elic acid okay and so you know when a strawberry is a little tartter because it's got more elic acid so um electric acid is a powerful starver of cancer so it cuts off the blood does that actually end up in our bloodstream like can could I eat strawberries and then you could draw my blood and be like you had seven strawberries absolutely okay now but here's here's the even more insane part what are these what are these bioactiv doing in the plant they are part of the plant's Health defense system so these natural chemicals help the plant defend themselves when we eat them they have another job description they do double duty and they actually help to activate our own body self defenses now here's one thing that I think is a practical um value you know for a long time people are sort of talking about like well you know like you should eat more organic and don't need pesticides and stuff like that here's a whole new take on this okay and this is kind of smoking hot information um pesticides actually kill insects so that the plants um look better um the leaves aren't as chewed up and usually the fruits or vegetables look a little bit better too right that's just agriculture makes it look better on the product look better on the Shelf organic doesn't use that and so a lot of times you you have the more natural you know the bugs are nipping at the leaves and chewing at the stems guess what Mother Nature created things like elic acid As Natural insecticides and so basically when the um the plant strawberry plant is being chewed on it makes more elic acid to repel the bugs it's a wound healing response and a defensive response so organic foods have more bioactives as a reaction I just was uh involved with a study uh I was meeting about yesterday talking about coffee organic versus con conventionally grown coffee conventional grown coffee with pesticides organic coffee hands down um this is a study at the University of Warsaw University um hands down um a pound-for-pound of coffee being organic coffee has more bioactives than the pesticide treated coffee because the insects the natural things in the environment cause it to create more natural health defenses dude this yeah this gets incredible I can't believe I'm this deep in my joury of health and all that and I never realized that the actual chemical compounds from food I always thought it was the metabolites from the the digestive process that was making its way into the bloodstream which I know also happens also happens yeah that's uh that's really intriguing so one thing we actually haven't talked a lot about which is your specialty is angiogenesis so when we eat something that has an anti-angiogenesis benefit is it like ubiquitous across every blood vessel in the body or is it doing something creating some sort of KnockOn effect like the antibody drip that we're getting where it's somehow selectively targeting things that are overproducing something great question let me kind of um frame it in uh uh first framing about androgenesis in general so when we were in our mom's wombs okay and sperm met egg and started to form a little ball of cells that didn't look anything like a person yet but started to create little organs and start to create shape the first organs that could created our blood vessels our circulation is the first thing that gets created so our blood supply our circulation is very much a part of who we are and I mentioned that we have 60,000 miles worth of blood vessels just to give you a sense of how extraordinarily big that is if you were to pull out all the blood vessels from from you or me and line them up end to end that would form a thread that would go around the earth twice huge okay it is insane now um our every single cell in our body every organ require um relies on just the right amount of blood flow so they're getting fed with oxygen and nutrients um uh they don't need more than just the right amount and but if they don't have enough our body has to be able to grow more okay this having just the right amount I call it the Goldilocks zone so Goldilocks remember the the the story um you know the Bears went in there and it's not too hot not too cold not too hard not too soft or our health defenses including angiogenesis is exactly the same way not too much and not too little but just the right amount so this just right Zone exists for our blood vessels our stem cells our microbiome our DNA kind of balance as well as our immune system it's all about homeo stasis the term you used earlier just the right amount now that means our body knows how to grow more when it's necessary and then when there's enough it stops and if there's too much it's kind of like a a gardener you know that sees your lawn over growing it mows the lawn mows it right back down till it gets to the right height okay our body's Health defenses when they're working at their best is like a perfectly manicured lawn not too much not too little just the right amount to be able to uh to to to go around like playing like rounds of golf on a perfect course now um what tumors do is they hijack this process and so they like a tumor is sitting on a golf course and just grows extra weeds and grass right just for itself so that's what gets targeted your body tries to fight that off but sometimes we need some extra help for it that extra help can be a smart bomb drug that we um designed to Target those extra blood vessels or we can help our body mow the lung by eating foods that have anti-angiogenic or blood vessel mowing capacity you'll never be able to get rid of them all it's just back down to the body's set point so what's an example of um a drug that can actually do this there's monoclinal antibodies that are designed like smart bombs that take out tumor blood vessels but foods can actually do it too now why can drugs and Foods Target a tumor blood vessel and not take down your aorta or the blood vessels feeding your brain like your cored artery it's because because when we build the healthy blood vessels we take our body takes great care to construct them to be very very strong it's like building a skyscraper okay The Architects and the contractors and their Craftsmen they make everything perfect as perfect as they can but when a tumor does it you know it doesn't it's not careful contractor it's like a lousy contractor just throws it the thing up and so the blood vessels are grown are flimsy they're fragile they're stable and so think about you know a hurricane like hurricane Ida sweeps through the area and the strong sturdy structures our healthy blood vessels are going to stay up even when the wind is there all the ones that are not well constructed the wind blows them right down and that's why a tumor blood vessel is much more vulnerable to either food or drug wow that that's really incredible okay so you wrote the book Eat to beat disease we've touched on a little bit but now I think it's worth what what is your sort of General I know that there's never going to be a one-size fits-all it's very important for people to understand but in terms of General uh patterns of eating to be disease what are those General patterns yeah well first of all um when I wrote EB disease which became a New York Times bestseller uh the whole point was not about writing about a diet it's not keto it's not South Beach it's not about weight loss even it's really about health and because when I was um doing my research to look at different foods that would activate our health defenses here's the first thing I was surprised by it's not like one food or two Foods or five foods or it was more than 200 different kinds of foods and they were fruits and they were vegetables they were spices and they were legumes and they were different kinds of seafood including shellfish and they were different kinds of fish Beyond salmon okay um and and there's even some dairy products that can actually have some benefits as well including fermented foods like yogurt and sauerkraut and kimchi and these foods are so ubiquitous that they are found in the traditional cultures of every single Society but especially Mediterranean diet which we know is healthier for us as a pattern and Asian food which we also know is healthier and so what I started to realize is that eating to beat disease is not just picking a particular disease and trying to figure out what the recipe is that the one size fits off but it's really um a journey that we have our whole lives from the time we're small until we get old we get older um parents have the opportunity to actually start feeding their children when as soon as they're taking solid food foods that can actually help them beat disease in fact in fact breastfeeding is actually helping your child um beat Disease by uh shaping and sculpting their microbiome right one of the health defense systems so I came up with 200 different foods I laid them all out According to which health defense systems they act activate some cases they activate all of the health defense systems I call those grand Slammers because man a single food will knock out you know knock the five Health defenses out of the park it's a home run to eat those things and I explain all the research that's been done by myself and other people to show how they actually work so what's the principle to eat to beat disease you can love your food to love your health love your food to love your health that seems so contradictory to what we used to think about healthy food right because the old thinking is that well you gotta eat healthy you got to cut out everything you love you know and and and I'm I'm turning that upside down inside out I'm inverting the whole equation I'm saying if you look at those 200 foods that I put down in my bookie to be disease take them Sharpie out and circle the ones that you love already I like this I like that one Tomatoes I like oh man I like this one okay that's a great starting point because if you start eating those Foods you're already ahead of the game because you already love foods that can actually eat that can activate your health defenses now you can explore expand your horizons by choosing these other foods that are out there as well if you sat in TV and watch a food a Food Network you can find all these people experimenting with different ingredients if you go on to YouTube you can look for an ingredient you don't recognize bitter melon the heck is a bitter melon well it's an Asian gourd is it bitter absolutely but there are ways of actually cooking it so it's not so bitter and it has medicinal value well how would I do it click on YouTube and search on recipe cooking bitter melon and you'll watch somebody teach it to you so love your food to love your health explore with your life and just know the foods I put in the book activate your body's Health defenses right and some of the things I know you've recommended um historically mostly P plant-based um you talk about getting some omega-3 from Marine sources uh whether it's from fish or whether it's from uh I I think you talk about seaweed you'd have to refresh my memory um you do personally eat some meat though I don't know if you eat any red meat or not I know you recommend that people cut that down uh extra virgin olive oil um things like that am I missing any of the the heavy hitting advice well I mean so here here's the basic thing um all the research scientific research has been done and the epidemiological the public health research shows that eating a plant-based mostly plant-based diet that that's pretty broad you know um uh fruits vegetables legumes nuts healthy oils good for you you should eat most of mostly that doesn't mean and by the way plant-based could be tricky because a lot of ultra processed foods also have um plant materials in it processed soy all kinds of other things all kinds of unhealthy oils made from Plants however it's whole plant-based Foods it's kind of stuff you'd find a grocery store or a farmers market okay like I would say mostly go for those mostly go for those okay um Seafood has been shown to improve survival and decrease the risk of death if you eat two or three servings of of seafood shell it could be F fish or shellfish um you get healthy omega-3 fatty acids is that per day per week two to three servings per week and the amount you would eat uh which I write a whole chapter about food doses um amount you would eat is about three ounces so people like well wait I'm not a human scale I have no idea what three ounces is what I would say it's a lot less than you think it is a piece of fish about the size of a deck of playing cards you can put it in your palm it's about y it's about as thick as a deck of playing cards not that big a deal and you know um and and people who love seafood can can get a lot of it that way recently there was an interesting study that showed if you actually increase your level of Omega-3s by an extra serving a week or two like from wherever you are with your starting point you can increase your longevity your surv surval by 4.7 years so an extra serving of of of of Omega-3 Rich Seafood you increase your Survival by LifeTime Survival by 4.7 years now you can get if you're a vegan or a vegetarian you can get Omega-3s from plant-based Foods so chia seeds flax seeds some of the nuts you can get those as well but what in plant-based Foods you get a different kind of substrate to make your Omega-3s so you got to eat a lot more of it so you know um I I I I like diversity so um plant whole plant-based Foods Seafoods if you actually eat fish um if you don't explore it if it's not for some ethical reason um and then you know look uh and dairy by the way you know when it comes to Food and Health there's no universals okay some dairy products you know like honestly cheeses are good for the microbiome because many traditionally made cheeses not in large quantities they've got saturated fats and a lot of salt but some cheeses actually have lactobacillus another healthy gut back bacteria that we can use as a probiotic food yogurt a dairy product probiotic food and so I'm all about the science wherever the science takes me is where the evidence takes me there is a great American novelist named elel Doo and he had this great uh quote he once said writing he's a novelist writing is like driving at night um you can't uh see beyond your headlights but you can make the whole trip that way and that's what science is like you just can only see where your headlights are going and you're focusing on the evidence and ignoring all the darkness that's out actually out there so what about meat okay um I can tell you that most of the research has been pretty convincing that if you eat a lot of red meat okay which was really only done for the last 70 years or so like you know since the 1950s um before that most societies didn't have we're we're not prosperous enough to have a ton of meat around okay and and now we have an abundance of meat that we've industrialized meat and all the things that are not so good for us but um all the studies show that eating a lot of red meat and all the Studies have shown that eating processed Meats we're talking about our sausages and the pepperonis and all kinds of other hot dogs all that kind of stuff um that's been classified by the World Health Organization as a carcinogen by the way processed meats you know once in a while especially if that's something you really enjoy don't worry about it knock yourself out enjoy it but do not do it all the time and if you can cut it down or cut it out more power to you better for you and so this whole idea about you know life is for the living got to enjoy our how we do things you know some things we enjoy aren't that good for us you know some people like to roll down the windows or take the top down and drive really fast on a on a road faster than the speed limit just don't do it all the time because one of these times you're gonna actually get into an accident right and so I think that idea of moderation but if you're informed by science and you can actually then listen into your body you feel like crap after eating something don't go for it don't eat it the next time or eat less of it the the science is just so rich at this point in time in history that you know anybody that wants to get into food as medicine as a science not as a trend that is a real science has a huge future ahead of them our body is actually hardwired with all the processes we need to maintain our health from the day we're born until our very last breath and what food s do is not something magical foods that we consume activate our body's own hardwired health defenses and that's actually why we don't get sick more often I love that and I think that's something quite unique about your approach when it comes to food and medicine I want to get into some specific Foods later on in this conversation but just to sort of um tease people as it were right the starts are there a couple of kind of facts about some specific foods that you think would be surprising for people that a lot of people may not be aware of yeah well uh first of all there are a there's a lot of Mythology about foods and some of it's wrong and when I say myth I'm referring to urban legends so as a bit of a teaser um most people most women have heard that soy should be avoided because it's dangerous so eating soy can uh increase your risk for breast cancer that is a common uh thought but it's completely false it is an urban legend research actually shows that those women who are at highest risk including women who have breast cancer the more soy they eat the lower their chances of death and so that's an example of an eye-opening uh fact that science Springs to the table about soy uh here's another one many people have heard that Tomatoes should be avoided because they're a member of the nightshade family which is poisonous and that Tomatoes contain a deadly toxin called uh lectins that should be avoided and it causes inflammation in the body well that's also completely wrong there are thousands of lectins out there Tomatoes happen to have some of the non-toxic ones um and in fact the studies of tomatoes have actually shown in more than 30,000 people that those men who eat just two to three servings of cooked Tomatoes a week have a 30% lower risk of developing prostate cancer and so again two examples of common foods that are surrounded by Urban modern mythology that science cuts through like a hot knife through butter in order to reveal what the true health benefits could be yeah thank you for sharing that and yeah later on in this conversation I'd love to get into some more more specifics around particular foods but I think at the start here just to sort of set the scene one of the things that really struck me about your approach is you know how you look at health and disease so many of us you know I'm a medical doctor I trained in the '90s in edor medical school you know we're trained how to diagnose disease and then treat it and sometimes we talk about preventing disease in the future but you sort of refrain FR that slightly didn't you to sort of ask yourself well why is it that we're not getting sick more often and I think that's a really beautiful that's a subtle distinction but it's but it's such a a beautiful way of looking at the human body so can you tell me a little bit about you know why did you frame it that way and by doing so what answers did you get that can help us all with our health and well-being yeah so like yourself during my education and training in medicine you know we're all uh responsible for digesting about 4,000 years of Western Medical knowledge in in a few years and then to be able to in short order turn that around into everyday practice for our patients right so that's a tall order just to begin with and most of it is about D learning how to um detect diagnose diseases accurately as accurately as possible and then coming up with essentially a text book solution I mean that's what we're taught to do uh from the very beginning recognize the disease recognize the solution try to match them up and then actually deliver that as as something that we can use to help our patients and and uh I did that for many many years and in fact I was so inspired by the um unmet needs for treating diseases some diseases successfully like cancer like diabetes like blindness frankly I wound up actually being starting a nonprofit organization called the angiogenesis foundation it's the charity where we as a third party set out to develop better treatments for all of these you know kind of unbeatable diseases looking for their disease common denominator I'm going to come back to common denominator in a second I felt that although you know billions of dollars had been spent towards cancer research or research to prevent blindness as just two different examples or breast cancer or or Alzheimer's disease progress in science was formidable but progress in treatment was way too slow and my thought was that if we could actually look at what makes diseases common and similar to one another rather than appreciate only what makes them different from one another so as a researcher we tend to take a take a study a field of study an inch wide and then dive a mile deep into exploring it what I wanted to do was to really upend that idea to say well maybe what we should do is take a look at many diseases and see what the common threads are because if we could find that Common Thread we might be able to pull the bow back and send the single Arrow more efficiently through multiple diseases to have an economy of scale of impact okay so when I did that we want up becoming enormously successful I've been involved with 41 about to be 42 FDA approved treatments for cancer di complications of diabetes and vision loss and with that kind of success one of the things that it made me realize was the power of science to generate evidence that something works and the other thing that I realized is that treating disease was highly valuable but really misses the mark of preventing the disease in the first place because if all we do as a sort of in our medical world is invent new things to throw at Old diseases in this NeverEnding progression then we're chasing really the tale of a beast that will never catch and I wanted to be able to actually figure out how to you know prevent the problem in the first place now a a short story about what actually happened that sparked me towards nutrition is uh I was a a doctor for many years in a veterans hospital this is a hospital in the US that takes care of people who are former soldiers and you know as a payback for their service uh they can come to a medical center uh and and receive essentially free care and I I felt compelled a duty actually when I finished my training to be able to pay back uh the people who helped to um support and defend uh the country and so I I took on a stint um at a Veterans Hospital these were some of my favorite patients uh they were uh they were grateful they were uh they had Rich lives they had amazing stories to tell and they were just nice people and unfortunately though they were pretty sick so most of the people that I saw were in their 60s and 70s and 80s were terribly obese they had diabetes heart disease cancer respiratory illnesses you name it they had these terrible problems and the thing that struck me that you know because here I was writing prescriptions and sending people The Specialist and having them have surgery and all these other interventions and I was very excited actually at the very beginning to be able to let them know some of the treatments that I myself had been involved with helping to develop but what I realized that was the IR is that these soldiers who were so terribly out of shape in the latter part of their lives were once cut fit buff physical specimens that couldn't have even served in the military unless they were in perfect shape and so I asked myself what the hell happened to these people yeah they were in great shape and now they're in terrible shape and that's what led me on sort of this um Odyssey to think back about what must of like what kept them from being sick in the early days and then what actually happened to their bodies that led them to deteriorate and that's where I came back to this health defense the health defenses that are hardwired in our body because like the so like like soldiers that they were you know they once were the Defenders of the country but um uh as they got older their ability to defend actually waned and and so too in our body I realized there's these biological systems that keep us fit keep us healthy and if we're not careful to take good care of them they too will W in their power to defend us and that's actually how we wind up getting sick yeah it's very powerful what you just shared about the veterans hospital because I think although that's in the latter stages of their life I'm sure there's many people listening to this right now or watching this who would have resonated with that on some level and thought hey you know what when I was at school I used to swim or you know maybe I was on the college or the university squash team or the tennis team and now in my middle age I've got a bit of uh extra weight I don't have as much energy so you know it's on a Continuum isn't it and and of course the end of that Continuum that's where we tend to get involved as medical doctors Western medical doctors at least and we say oh you have this disease now but actually I think it's a very powerful way of just showing gradually without us realizing as we're you know getting on with our daily lives our health can be deteriorating bit by bit in terms of these defense systems you also mentioned at the start of this conversation the word resilience and how what you try and do or or certainly food when used as medicine can really help us with that resilience perhaps could you take us through these defense systems that you've learned about because I know you've identified five of them I think that would be really interesting for my audience what those are and then I think we'll get to well what can we actually do about each and every single one yeah well let's talk a little bit about resilience first before I talk about the health defenses so think about how resilient the human body is right I mean uh we can take we can take a punch and we can get back up on our feet pretty easily throughout most of our Lives um our body knows how to heal so if you wind up getting a cold you tend to recover from it if you get a cut on your skin it tends to heal up um if our belly gets upset and we wind up uh you know uh uh feeling we're in a toilet uh in ways that are not comfortable for us we'll generally rebound back to our normal health I mean that's really most of the experiences that we have as we're younger and that resilience actually is quite an amazing thing because it has to do with this concept that we learn as doctors which is homeostasis our body wants to stay in a homeostatic position and that means like a gyroscope you know or like a big ocean liner you know sailing through you know rough Seas there is kind of a set point that no matter how big the waves are we tend to kind of stay our center of gravity is where everything wants to get back to and that is actually critical Health now how what's the gyroscopes of our health how do we actually maintain our balance how do we how do we Veer off to the side but rebound back to that Center Point our own center of gravity and that's where these Health defenses actually come into play so uh our health defenses uh which I'm going to tell you f the five of them in a moment actually started to be developed in our bodies when we were still in our mom's womb so when our mom's egg met our dad's sperm and fertilized in the womb within about four or five days these cells primitive cells uh and stem cells wound up forming our organs you know our our our circulation our hearts our brains our noses our hands our our feet our bones and along the way at the same time our body form these remarkable defenses now these defenses are designed to protect our bodies the same way that in a European Fortress a medieval Fortress there are these defenses right yeah you have the moat you actually have the drawbridge you have those Arrow slits that you can shoot out of you've got the curved wall all these defenses that you find in a castle there is a counterpart in our body in in our body our defenses to keep us healthy and and resist disease and help us maintain resilience are the following number one we have a defense called angiogenesis angiogenesis two words uh it's actually one word but it's two component parts of it angio meaning blood or blood vessels Genesis meaning growth so it's how our body grows blood vessels our circulation and the reason blood vessels are a defense system is because we've got 60,000 miles worth of blood vessels packed into the average adult body and these are the highways and byways that deliver blood oxygen that we breathe and the nutrients from the food we eat to every single cell in organ and if we don't have enough of these blood vessels our our tissues our organs starve and many times they'll die so we need to our body needs to be able to maintain enough uh blood vessels enough circulation and on the other hand if we've got too many blood vessels and overage overgrowth that would be like a um a garden that overgrows with weeds those weeds actually obscure the function of a garden and they can actually destroy our health by feeding diseases extra blood vessels can feed diseases like cancer as an example or arthritis or psoriasis or many other types of harmful uh extra blood unwanted blood vessels and so the body maintains its resilience in circulation by literally maintaining a balance this set point this gyroscope center of gravity and the way that I tell people it's kind of like the old um fairy tale Goldilocks so not too many blood vessels not too few blood vessels just but just right like the Three Bears yeah the not too hard not too soft not too hot not too cold just right this is a paradigm that follows all the health defenses so blood vessels are one of them secondly are our stem cells remember I said that we formed in a womb with stem cells yeah well when we're born we have extra stem cells left over that we're not used so it's kind of like painting a room uh if you're painting a room and you're going to buy paint right you always buy extra paint because the last thing you want to do is to run out of paint before you finish the job what do you do when the when the room has been completed from painting you've got extra cans of paint so what do you do you put the cap on you put it in your garage okay for for another time if you need to spot check well this is actually what happens with our stem cells when we're born and our organs have formed all these stem cells the ovary and we've got extra stem cells in fact we've got 750 million extra stem cells when we're born that gets packed up into our bone marrow where it basically sits for most of our Lives until we need to repair our organs from the inside out so regeneration our ability to be able to renew ourselves is another Health defense system the third one is our gut our gut microbiome so much has been made of how important our gut bacteria is um I will tell you we're just stretching the of the iceberg of understanding our gut bacteria but I will tell you it is so important that we've got about roughly the same number of bacteria growing inside our body as we actually have human cells and Beyond bacteria there's even viruses that are healthy viruses um I just learned this the other day you know we've got about 39 trillion bacteria growing inside our body most of them are healthy and as you know when we were in medical school we were all taught you know we drank the Kool-Aid that bacteria are bad and so one must destroy bacteria and hence there are antibiotics to match with bacteria but in fact most bacteria in our bodies are good and occasionally there is a bad actor that kind of Springs out and and so uh the the but what I learned was that there are good viruses as well in fact there are 10 times more viruses in and on the body than than bacteria so it's 380 trillion viruses the human viral our DNA is hardwired is a fourth Health defense system hardwired to protect itself against damage from the environment like ultraviolet radiation radon from the ground any chemicals solvents we might inhale oxidative stress even emotional stress which can actually Fray Our our DNA our genetic code our DNA can protect that and of course finally our immune system which like a uh like the volume switch on a car radio is perfectly tuned to be able to deliver a little inflammation where it's needed a lot of immune protection to be able to ward off Invaders from the outside like bacteria and viruses and Invaders from the inside like cancer and that whole system like a volume switch on a radio needs to be able to turn up and when you've had enough to turn it back down and and back down to that homeostatic balancing point that set point and for all these Health defense systems our body kind of chugs along through life getting keeping us right sort of Steady As She Goes every now then it's got to rear up um and and swash buckle to get rid of some disease but it comes right back to Center uh and that's what foods can actually help the support hi there if you enjoyed watching this video I know you'll love the next one stay here and check it out and I'll see you there