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Language: en
When you actually have imunotherapy, you
can take people with stage three and
even stage four cancer. That's like
endstage game over no win situation
cancer and you can with your own immune
system tackle that cancer and you can
turn stage 4 to stage zero. It's
actually in some ways a lot nastier in
terms of the chemicals that are involved
than cigarettes and tobacco. And by the
way also lower the risk of developing
certain forms of cancer including
colorectile cancer as well. for every 5
to six grams of if a patient with
melanoma is getting treated with
imunotherapy and reduced mortality by
30%.
[Music]
[Applause]
First of all, what is colon cancer? It's
a cancer of your bowel. That's the lower
part of your intestines. And it's one of
the most common cancers affecting both
men and women. And it's starting to be
diagnosed in younger and younger people.
When I went to medical school, it was
unusual to have somebody who was
50-year-old getting colon cancer, being
diagnosed with colon cancer. And now
we're actually seeing people in their
30s and even in their 20s and even uh
some teenagers have been reported being
diagnosed with colon cancer. So what is
going on? I think to understand what's
going on, we need to review this
condition and think about the things
that we can do to lower our risk. What
are the things that if we have it um we
can actually use to treat and of course
how do we actually stay as healthy as
possible to avoid any kind of cancer in
terms of in including colon cancer. So
watch this video to the very end and I'm
going to give you some practical tips.
Majority of cancers are really due to
diet and lifestyle. only the minority
are are due to genetics. All right? So,
diet and lifestyle is what we think is
the reason why people are being
diagnosed earlier and earlier with colon
cancer. All right? That's a real
surprise and a real concern as well.
It's unlikely to be a big gene mutation
that's actually occurring. And so, we're
beginning to ask the question, is it
something in our environment? Is it a
toxin we're exposed to? Is it water? Is
it microplastics? Is it something in our
food? Is it something we're eating? Is
it something we're not eating that we
should be eating that sets us up for
this? Why do we think it might be
something that we're eating? Well, if
you take a look at some of the dietary
risk factors for colon cancer, you have
things like alcohol, which put you at
higher risk for colon cancer, but also
uh eating processed meats. Uh processed
meats are considered a carcinogen. And
you know that um anybody who is a health
seeker will hear from experts that you
should cut down or cut out processed
meats, hot dogs, bologoney, salami, all
those deli meats. All right. Um they
have actually been classified as a
carcinogen by the World Health
Organization meaning that they are
linked they are associated high intake
is associated with the development of
many cancers but especially colon
cancer. Think about it. You're eating uh
processed meats. They're going down.
They're parking themselves in your colon
before they get pooped out. What's left
gets pooped out. We think that the
chemicals in there, the nitrosamines,
the TMAOs, all those types of things
that can be formed by processed meats
actually are setting up for that
inflammatory um environment. Okay,
lifestyle, diet can be important, but
let's talk a little bit about lifestyle.
Smoking increases the risk of
colorectile cancer. All right. So, we
used to talk about cigarette smoke, but
now we're also thinking about vaping.
All right. Vaping is actually in some
ways a lot nastier in terms of the
chemicals that are involved in the
vaping liquid than cigarettes and
tobacco. So, if you smoke, don't smoke.
All right? That's actually something
that's good for your lungs, but also
good for your lowering your risk of
other cancers by cutting out and not
smoking anything. Alcohol is is is
another one. Sedentary lifestyle is
another lifestyle risk factor. If you're
sitting around all day, you're not
exercising, you're not moving. All
right? Um, pretty much, uh, your gut
microbiome isn't going to be as healthy,
your levels of inflammation might go up,
uh, your metabolism is going to be out
of whack, your hormones are going to be
out of whack. All the things that happen
when we don't exercise. Move regularly.
All right? uh even taking a walk can
actually make a difference in terms of
helping your overall health including
your immune system. And that brings me
to something that's really important
because what does smoking do? What does
alcohol do? What does a sedentary
lifestyle do? Well, it actually not only
causes more inflammation in your body,
which is a setup for all kinds of
cancers, including colorectal cancer,
but they alcohol, smoking, sedentary
lifestyle, and eating ultrarocessed
foods with additives, preservatives,
they actually suppress your immune
system. Okay? And so, if you don't have
a good immune system, you your body is
compromised in one of its most important
health defense systems against cancer.
Now, I wrote about this in my book, Eat
to Beat Disease. All right, you might
have seen this if you haven't. And this
is a book that's not about disease. It's
about health. But there's a lot in here
about what you can do to lower your risk
of cancer, including colurectal cancer.
There's some new developments that I
think are very, very exciting. Uh, and
that's imuno theapy, immune therapy. So,
what is imunotherapy? Well, imunotherapy
is a treatment that isn't a it's not
chemo. It's a treatment that actually
activates your own immune system to go
after the cancer, right? It activates
one of your body's own defenses, which
is your immune system. Now, in my book,
Eat to Beat Disease, I write about your
body's five health defense systems, and
your stem cells, your gut microbiome,
which can lower inflammation, has a way
of fighting cancer, your DNA protection,
and your immune system. And your immune
system is literally an army of super
soldiers that patrols your body at all
times looking for trouble. When I say
looking for trouble, they are like a cop
on a beat policeman cruising through the
neighborhood making sure there is no
trouble, but they're looking for
trouble. If they spot it, they'll write
to the site and they'll take out the
problem. And that problem in your body
could be a microscopic cancer. All
right? So your immune system is
responsible for spotting and knocking
out little tiny microscopic cancers long
before they can grow a blood supply to
become a problem. Now I can tell you the
blood supply issue is a really major
one. All right. Now I came I was trained
in a lab that studied uh blood vessels
and uh and tumors and it turns out if
you prevent blood vessels from touching
a tumor which is what your body tries to
do it can't grow. Okay? Okay, it can get
about to 2 to 3 millimeters in diameter.
That's about the size of the tip of a
ballpoint pen. Okay, then it can't get
any bigger because it doesn't have
oxygen. There's no blood vessels feeding
it. It doesn't get nutrients. All right?
Uh you need you need air and you need
food in order to grow. So the cancer
sits there like a a small microscopic
head of a pin size tumor and your body
controls it that way and naturally
anti-androgenic. All right. Now what
happens? Your immune system wings by,
spots that little tiny abnormal cells,
takes it right out. All right, that's
actually how your body controls it. So
if there's a cancer that's already
grown, we can give medications for
colurectal cancer that cut off the blood
supply. One of them is called
bevvisismab or also known as avasten.
You know, it cuts off the blood vessels
feeding and it's approved for colorectal
cancer. also works for brain tumors,
ovarian cancer, cervical cancers, lung
cancers, a number of other cancers. It
all actually has um a benefit by cutting
off the blood supply. What we found in
the lab is that when you cut off the
blood supply of tumor, it can't grow. In
the lab, there are research studies that
have shown that if you if you prevent
that blood vessel the tumor from ever
getting a blood supply, it can't grow.
But in an experiment, if you allow blood
vessels to reach and touch and start
feeding tiny microscopic cancer, you
know what? It can grow 16,000 times in
size in just 2 weeks. So, angiogenesis
out of control. So, think about blood
vessels gone wild. You've heard of girls
gone wild. This is blood vessels gone
wild. Feeding a cancer can cause
explosive cancer growth. That's why
anti-angioenic
uh treatments are a very important uh
foundation now for treating colurectal
cancer and other types of cancer as
well. Now I started talking about
imunotherapy and that actually uh is
also important because the other
knockout punch naturally in your body is
your immune system. So imunotherapy
jacks up your own immune system. All
right. To and and when your immune
system is stronger, it's like not just
two cops in a in a patrol car in a
neighborhood. Now you get the whole
army, the whole entire police forces
out. Now you've got a really really
strong army in order to be looking uh
out for and and capturing and going
after those bad guys which are your
cancer cells. So imunotherapy it is
literally a transformative revolution in
oncology in in the treatment of cancer.
By getting your own immune system to
wipe off cancer you're able to achieve
something that we only dreamed of before
which is to take the most natural
process your own immune system raise
those shields of that defense in order
to be able to knock out the cancer. And
by the way, we've actually been able to
find that when you actually have
imunotherapy, your own immune system
working in the best possible way, you
can take people with stage three and
even stage four cancer, that's like
endstage, game over, no win-win
situation cancer. All right? And you can
with your own immune system jacked up,
you can actually tackle that cancer and
you can turn stage four to stage zero.
It is not happening for everybody yet.
We have a lot of work to do to figure
out in research how to make more people
respond, but we're beginning to discover
that if you actually um give people with
colon cancer who are going to respond to
imunotherapy, you can really have a
dramatic response. There's a number of
people out there on social media that
are talking about their stories on
imunotherapy. Uh one of the most
important ones are called checkpoint
inhibitors. Um, you've probably heard uh
some of them uh talked about uh uh on
commercials like Katruda. Uh the actual
drug name is called Pembbrismab. But
these checkpoint inhibitors actually
they pull the cloak off of a cancer so
your immune system can spot the cancer
that's been trying to hide from your
immune system and then your immune
system goes a after it. In order for
imunotherapy to work, these checkpoint
inhibitors, we know that one marker that
you look for is when you get the tumor
biopsy, you send it away, you're looking
for markers that would uh suggest that
you're going to benefit from
imunotherapy. So there's markers like
microatellite instability. The tumor is
very unstable. It's going to be more
susceptible to imunotherapy. Um there
are targets called PD1 and PDL1. Uh
those are um markers that um the
pathologist will look for after getting
the biopsy, the surgical specimen. Um
and these are things that you should ask
for if you're having if you're diagnosed
with cancer, colon cancer, but other
cancers. You know, you should ask, have
you should ask your doctor, has my tumor
been uh sent away to see if I can be
treated with imunotherapy? And for the
checkpoint inhibitors, you're looking
for MSI, microatellite instability, high
levels of that MSIH. Looking for markers
that suggest a tumor is cloaking itself.
PD1, PDL1. All right, those are some of
the signals that your cancer might be
immunable to imunotherapy. Your gut
microbiome. Now, we already talked
started talking about the gut
microbiome. healthy bacteria lowers
inflammation. It improves your
metabolism actually puts you in a better
mood. The gut brain axis as well and a
good healthy gut bacteria lowers the
risk of many different types of diseases
including cancer. We think that abnormal
gut flora gut bacteria unhealthy
neighborhood we call it dispiosis may
wind up being one of the contributors
one of the factors in cancer that's been
hidden in plain sight all these years.
So now there's a lot of research looking
at that. So what are the foods that
actually can help your gut microbiome?
Foods with polyphenols, colorful foods,
whole plant-based foods, you know, when
you go to the produce section of the
grocery store, the farmers market, all
those colorfuls, bell peppers, berries,
all the different colorful greens that
are out there packed with polyphenols.
All right, those actually are really
favor help to grow growth of healthy
bacteria. But dietary fiber is
particularly important. In fact, one
study showed that for every five to six
grams of dietary fiber, which is the
amount you'd find in a medium-sized
pair, if a patient with melanoma is
getting treated with imunotherapy, it
reduced mortality by 30%. whole
plant-based foods, and that's fruits and
vegetables, nuts and legumes, herbs and
spices. They all have the polyphenols
that actually feed your gut microbiome,
healthy gut bacteria, which then lower
inflammation, also activates your immune
system. You can cut down on uh or cut
out eating processed meats. You can
actually have a healthier lifestyle by
uh avoiding excess alcohol. Don't smoke.
All right? Cut down drinking. Stay
physically active. Lower your stress.
All right, that seems to be one of the
contributing factors to developing
cancers as well. Listen, this is a tall
order, right? There's a lot of things in
your life you got to control. You can't
control everything, but when it comes to
using food, we got to eat three times a
day. I'm just telling you, there's a way
to actually eat more dietary fiber, more
polyphenols. And by the way, coffee and
tea also lower the risk of developing
certain forms of cancer, including
colorectile cancer as well. tea. Green
tea contains polyphenols called kakans
that are powerful ways to cut off the
blood supply to cancer. I write about
this in my book, Eat to Beat Disease. If
you haven't read it, I'd recommend the
book through you. It's got a ton of of
cancer preventing cancer starving uh
foods in there. Coffee also has
chlorogenic acid which also lowers
inflammation and is also uh cancer
starving uh as well. vegetables that
actually have cancer starving
properties. Brassica vegetables, so
broccoli, Brussels sprouts, kale,
arugula, isothiocyanates. These are
sulforophanes, natural chemicals that
can actually cut off the blood supply
feeding a cancer and also lower
inflammation. Beans, legumes, white
beans, black beans, pinto beans,
chickpeas, soybeans, edamame, all of
those actually are rich source of
dietary fiber. Olive oil. Extravirgin
olive oil contains polyphenols like
hydroxyol oolocanthol. Those also lower
inflammation and have cancer starving
properties as well. And omega-3s,
seafood with healthy omega-3s. Now, we
used to think it was only salmon or
lower on the food chain like anchovies
and sardines, mackerel, but in fact,
even cod and halibit and even shrimp and
shellfish like muscles and clams, they
also have healthy omega-3s. Omega-3
fatty acids um actually cut off the
blood supply to cancers, anti-angioenic,
lowers inflammation. All of this can
contribute to lowering your risk of
developing cancers including colorectal
cancer. So these are very important
little tips that can actually make with
food that can make the drugs that are
the cutting edge of cancer therapy work
even better. That's not food versus
medicine. That's food and medicine. And
I'm a big believer that the right
medicine for the right person at the
right time can be life-saving and is
absolutely important for the medical
community to use to help patients. But
what patients do for themselves when
they're not at the doctor's office and
at home looking in the pantry or in at
at the stovetop or looking in the
fridge, that can be absolutely vital for
helping your body's health defenses get
stronger so your own body is uh able to
amplify whatever it is the drugs are uh
designed to do. All right, very very
important thing. Iapy, get an infusion
for these checkpoint inhibitors. get it
every 3 weeks or so. Um, you can get it
alone. You can combine it with chemo.
Sometimes you can double up the
imunotherapy. The people are really
trying to figure out how to do this
really, really well. We don't know how
to make it happen for everybody, which
is really uh one of the huge challenges
in cancer research today, but we're
beginning to have some clues. One clue
is that you need to have the a healthy
gut microbiome. Remember, uh, your gut
microbiome, these 39 trillion bacteria
that live in your gut, in your colon,
um, in the seeum, which is a pouch, uh,
in your colon, actually uh, do really
good things for us. They lower
inflammation, which is really, really
important. Help improve our metabolism.
Uh, the gut and brain are connected.
They even help us uh, be in a better
mood. But here's the thing. Uh there was
a research study that was done in 2017
looking at people that were getting
cancer patients who were getting
imunotherapy these checkpoint inhibitors
and what was found is that there were
people that responded meaning that they
did really well their immune system
jacked up and knocked out the cancer and
there were people who didn't do so well.
All right. Uh and they were
nonresponders. Okay. And nobody
understood why. And when the research
which was performed at the institute
Gustaf receiva my colleague Dr. Lauron
Zitfogle um looked at the differences
between responders and non-responders.
You know what she found? She found there
were bacteria that made the difference.
All right? It wasn't genetics, it wasn't
lifestyle. It was a bacteria. And one of
the bacteria that was discovered, I'm
sure you've heard me talk about this
before, is called acrimancia
mucinophilia. Acromancia mucinophila and
in that study which was published in the
journal of science the patients who had
acromancia tended to respond to
imunotherapy very important single
bacteria can make the difference between
responding and the people who didn't
have it tended not to respond man is
that an important finding like it was a
jaw-dropping finding because it we
started to realize just how powerful our
gut bacteria might actually be now in
2017 there weren't really any probiotics
you could
And so the way uh the research was
conducted was the researcher Dr. Zipogle
took the acromancia from patients who
responded and transplanted it in the lab
to animals who didn't have acromancia
and who weren't responding to
imunotherapy in the lab. And guess what?
When you transplanted the human
acromancy to the animal, boom, the
animal would begin to respond to
imunotherapy. That's a pretty good piece
of evidence, you know, uh that that this
bacteria becomes really important. Now,
how do you grow acromancia naturally?
It's naturally a healthy gut bacteria.
We know that you can give elagitanins.
You can eat foods with elagitanins like
pomegranate, like dried cranberry, like
conquered grape juice. Um and there are
other bioactives that we're beginning to
discover can also grow acromancia. Oats,
oatmeal can grow acromancia. whole grain
chili peppers, you know, the stuff you
put on a pizza, those dried chili
flakes, they have been found to
stimulate the growth of acromancia.
Chinese black vinegar, that's the kind
of vinegar they serve in soup dumplings,
that has been shown to grow acia as
well. We don't have all the answers of
of how to do everything for acromancia
and now you can take a probiotic as
well, but I can tell you that this is
the kind of research that is moving us
forward. First we have imunotherapy.
Then we look at the responders. Then we
find a bacteria. Now we're understanding
how to nurture the bacteria. Now we're
going to have a probiotic to help it. So
in the future, what I anticipate, what I
forecast is that we're actually going to
be combining probiotic therapy and
microbiome nurturing along with
imunotherapy. And this is really going
to be really a very very powerful uh uh
partnership. Your gut bacteria working
with your immune system. Oh, didn't I
tell you your gut microbiome and your
immune system are two of your five
health defenses? See, this is all about
helping the body unleash its own healing
and disease fighting capabilities,
right? And we're beginning to find this
now. If you're a cancer patient, you
should ask your doctor beyond surgery,
beyond chemotherapy, beyond radiation,
what else is out there for me? Can I get
a cancer starving anti-angioenic
treatment? Um, is there another targeted
treatment I should uh have? Has my tumor
been sent for analysis to see if I'm
eligible? Am I likely to respond to
imunotherapy? Can I get an immune
boosting treatment so my own body can
fight the cancer in a jacked up sort of
way? All right, you should ask about
that, right? Like anybody with cancer
should be asking, can I get
imunotherapy? uh and uh looking it up.
There are lots of clinical trials now as
well. So if you go to
clinicaltrials.gov,
that's a website and you type your
cancer your interest in imunotherapy,
you can do your own search to see what
kinds of clinical trials are actually
going on. All right? So I'm not telling
you that there's a definitive answer.
I'm telling you we are at the point
where things look so promising that we
have to actually go after that direction
of hope that's real which is
imunotherapy and foods that you eat the
polyphenols the dietary fiber all right
can amplify your gut bacteria gut
microbiome lowering inflammation so this
is exciting this is important uh cancer
is a very scary topic but I just wanted
to share with you as somebody who is a
doctor, who is a researcher, who's been
involved with cancer research and cancer
drug development, I'm going to tell you
this is there's never a good time to
actually um have a cancer diagnosis. But
now people who are facing cancer, who
are being treated with cancers, have
real hope and it's up to you to advocate
for yourself with your doctor to look
for those right treatments, including
imunotherapy. All right? Now, not
everyone's eligible for it, but you
should definitely ask. All right. And
see if you can get it. And it's up to
you to know that the foods that you eat,
those anti-inflammatory foods, pull
plant-based foods, um, actually can ramp
up your immune defenses and your gut
microbiome to tip the odds in your
favor. Hey, if you like that video, then
you're going to love this one. Check it
out.